http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2561654-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-08 |
| filingDate | 2010-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2c6f60ce15398c9ddf14c80465187af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faa0a9b7a3610cc78fa0d9af920df399 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae31536459b5a4497db15a96da4463b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_251f44bd1ee07e3c904d848e3aef6a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_131cd4e6903454bf0f013d3e62da388b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09ba22fe11954c5e8db9dfa341bf03cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41563ac3357b849aa3c26a369cb15988 |
| publicationDate | 2016-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2561654-T3 |
| titleOfInvention | Potassium channel inhibitors of the renal external medulla |
| abstract | A compound having structural Formula I: ** Formula ** or pharmaceutically acceptable salts thereof, in which: ** Formula ** represents a heterocyclic ring selected from the group consisting of: Z1 is selected from the group that consists of: ** Formula ** Z2 is selected from the group consisting of: ** Formula ** X is selected from the group consisting of -H, -OH, -O-C1-3 alkyl, -F, oxo , NH2 and -CH3; Y is selected from the group consisting of -H, -OH, -O-C1-3 alkyl, -F, oxo, NH2 and -CH3; X1 and Y1 are each independently selected from the group consisting of -H and -CH3; X2 and Y2 are each -O-; provided that when X is oxo then X1 is absent and when Y is oxo then Y1 is absent; and also provided that when neither X2 nor Y2 are present, then at least one of X and Y is selected from the group consisting of -OH, -O-C1-3alkyl, -F and oxo; R1 and R2 are each independently selected from the group consisting of -H, -halo, -C3-C6 cycloalkyl, -OR8, -SR8, -SOR8, -SO2R8, - (CH2) nOR8 and optionally substituted C1-C6 alkyl with 1-3 of -F; one of R3a and R3b is selected from the group consisting of -CN and -NO2 and the other is Re; one of R4a and R4b is selected from the group consisting of -CN and -NO2 and the other is Rf; R5 and R6 are each independently selected from the group consisting of -H, -C1-6 alkyl, -C3-6 cycloalkyl, -CF3, -CHF2, -CH2F and -CH2OH; R7 is selected from the group consisting of -H, -CH3, -CF3, -CHF2, -CH2F and -CH2OH; Ra and Rb are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C1-6 alkyl optionally substituted with 1-3 of -F, (d) -C3 -cycloalkyl- 6, (e) -O-C1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR8, (g) -CO2-C1-6 alkyl optionally substituted with 1-3 of -F, (h ) - (CH2) nOR8, (i) -SR8, (j) - SOR8, (k) -SO2R8, (l) -NHCOR8 and (m) -NHSO2R8; Rc and Rd are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C1-6 alkyl optionally substituted with 1-3 of -F, (d) -C3 -cycloalkyl- 6, (e) -O-C1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR8, (g) -CO2-C1-6 alkyl optionally substituted with 1-3 of -F, (h ) - (CH2) nOR8, (i) -SR8, (j) - SOR8, (k) -SO2R8, (l) -NHCOR8 and (m) -NHSO2R8; Re and Rf are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C3 -cycloalkyl- 6, (e) -O-C1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR8, (g) -CO2-C1-6 alkyl optionally substituted with 1-3 of -F, (h ) - (CH2) nOR8, (i) -SR8, (j) - SOR8, (k) -SO2R8, (l) -NHCOR8 and (m) -NHSO2R8; n is an integer selected between 1.2 and 3; and R8 is independently selected at each occurrence from the group consisting of -H, -C3-6cycloalkyl and -C1-6 alkyl optionally substituted with 1-3 of -F. |
| priorityDate | 2009-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1021.