| abstract |
A derivative of aminopropylidene or salt or hydrate thereof that is pharmaceutically acceptable, wherein the aminopropylidene derivative is represented by the following general formula (I): ** Formula ** in which R1 and R2, which may be identical or different, they represent a hydrogen or a substituent selected from the following (a) to (c), with the proviso that both are excluded hydrogen: (a) a carbonyl substituted with hydroxyl, alkoxy or hydroxyalkylamino, (b ) a carbonylalkyl substituted with hydroxyl or alkoxy, and (c) acrylic acid including an alkyl ester thereof, R3 and R4, which may be identical or different, represent a hydrogen, an alkyl that may be substituted with phenyl or a cycloalkyl, or R3 and R4, which together form a heterocyclic ring with a nitrogen atom attached thereto, represent a pyrrolidino, a piperidino that may be substituted with oxo or piperidino, an alkyl substituted piperadinyl or phenyl, a morpholino or a thiomorpholino, one of X and Y represents a carbon and the others represent a sulfur, and a wavy line represents the cis form and / or the trans form. |