http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2561163-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1dfab31402f484cf3b32ddfbc4bc1c5c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d0879da1d72f9372ddd58a3e3c75a72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a28e9ef9cc3c78c5c520d65676aaef22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77e6a040f0631488f81b0b906d0a3659 |
| publicationDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2561163-T3 |
| titleOfInvention | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents |
| abstract | A compound selected from the compounds of the following formula and the pharmaceutically acceptable salts, hydrates and solvates thereof: ** Formula ** in which: Ar1-Ar2- is independently a group of the following formula: ** Formula ** q is independently 0, 1, 2, 3 or 4; r is independently 0, 1, 2, 3, 4 or 5; each RP is independently a substituent on the ring; -RN is independently -H or a C1-6 alkyl; -Ar3- is independently 1,3-phenylene or 1,4-phenylene, and is unsubstituted or independently substituted with one or more substituents, -RAR3, wherein each RAR3 is independently a substituent on the ring; -Z is independently -OH or -O-W; -J- is independently -Ralq-; -Ralq- is independently a saturated aliphatic C1-5 alkylene, and is unsubstituted or independently substituted with one or more substituents -RAA, wherein each -RAA is independently: -F, -Cl, -Br, -I, - OH or -OMe; -W is independently: -RE1, -C (> = O) -RE2, -C (> = O) -O-RE3, -C (> = O) -OS (> = O) 2ORE4, -C (> = O) - (CH2) nC (> = O) ORE5, -C (> = O) - (CH2) n-NRNE1RNE2, -C (> = O) - (CH2) n-NRNE3-C (> = O ) RE6, -C (> = O) - (CH2) nC (> = O) -NRNE4RNE5 or -P (> = O) (ORE7) (ORE8); where: each n is independently 1, 2, 3 or 4; and each of RE1, RE2, RE3, RE4, RE5, RE6, RE7, RE8, RNE1, RNE2, RNE3, RNE4 and RNE5 is independently -H, C1-3 alkyl, phenyl or -CH2-phenyl; wherein each phenyl is optionally substituted with one or more groups selected from: -F, -Cl, -Br, -I, -RA3, -CF3, -OH, -ORA3, -OCF3, -NH2, -NHRA3, - NRA3 2, -C (> = O) NH2, -C (> = O) NHRA3 and -C (> = O) NRA3 2, where each RA3 is independently C1-4alkyl; wherein each substituent on the ring is independently: -F, -Cl, -Br, -I, -RD1, -CF3, -OH, -ORD1, -OCF3, -SH, -SRD1, -CN, -NO2, -NH2 , -NHRD1, -NRD1 2, -NRN1RN2, -C (> = O) OH, -C (> = O) ORD1, -C (> = O) NH2, -C (> = O) NHRD1, -C ( > = O) NRD1 2, -C (> = O) NRN1RN2, -NHC (> = O) RD1, -NRD1C (> = O) RD1, -NHC (> = O) ORD1, -NRD1C (> = O) ORD1, -OC (> = O) RD1, -C (> = O) RD, -NHC (> = O) NH2, -NHC (> = O) NHRD1, -NHC (> = O) NRD1 2, -NHC (> = O) NRN1RN2, -NRD1C (> = O) NH2, -NRD1C (> = O) NHRD1, -NRD1C (> = O) NRD1 2, -NRD1C (> = O) NRN1RN2, -NHSO2 RD1, -NRD1SO2RD1 , -SO2NH2, -SO2NHRD1, -SO2NRD1 2, -SO2NRN1RN2, -SO2RD1, -OSO2RD1, -P (> = O) (OH) 2, -P (> = O) (OH) (ORD1), -P (> = O) (ORD1) 2, -OP (> = O) (OH) 2, -OP (> = O) (OH) (ORD1), -OP (> = O) (ORD1) 2,> = O, > = NRD1,> = NOH or> = NORD1; and wherein additionally two adjacent substituents on the ring may together form a group -O-L1-O-, wherein L1 is independently a saturated aliphatic C1-3 alkylene; and in which: in each group -NRN1RN2, RN1 and RN2, taken together with the nitrogen atom to which they are attached, they form a 5-, 6- or 7-membered non-aromatic ring having exactly 1 heteroatom in the ring or exactly 2 ring heteroatoms, wherein one of said exactly 2 ring heteroatoms is N and the other of exactly 2 ring heteroatoms is independently N or O; each RD1 is independently -RD2, -RD3, -RD4, -RD5, -RD6, -L2-RD3, -L2-RD4, -L2-RD5, or -L2-RD6, where: each -RD2 is independently a C1-alkyl -6 saturated aliphatic; each -RD3 is independently phenyl; each -RD4 is independently a C5-6 heteroaryl; each -RD5 is independently a C3-6 cycloalkyl or a C3-6 cycloalkenyl; each -RD6 is independently a non-aromatic C3-6 heterocyclyl; and each -L2- is independently a saturated aliphatic C1-3 alkylene; and wherein: each C1-6 alkyl, phenyl, C5-6 heteroaryl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 heterocyclyl and C1-3 alkylene is optionally substituted with one or more substituents selected from: - F, -Cl, -Br, -I, -RF1, -CF3, -OH, -ORF1, -OCF3, -SH, -SRF1, -CN, -NO2, -NH2, -NHRF1, -NRF1 2, -NRN3RN4 , -C (> = O) OH, -C (> = O) ORF1, -C (> = O) NH2, -C (> = O) NHRF1, -C (> = O) NRF1 2, -C ( > = O) NRN3RN4, -L3-OH, -L3-ORF1, -L3-NH2, -L3-NHRF1, -L3-NRF1 2 and -L3-NRN3RN4; wherein: each -RF1 is independently a saturated aliphatic C1-4alkyl; each -L3- is independently a saturated aliphatic C2-5 alkylene; and in each group -NRN3RN4, RN3 and RN4, taken together with the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered non-aromatic ring having exactly 1 heteroatom in the ring or exactly 2 heteroatoms in the ring , wherein one of the said exactly 2 heteroatoms in the ring is N and the other of the exactly 2 heteroatoms in the ring is independently N or O. |
| priorityDate | 2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 169.