http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2560787-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4add7e8af694d8c07c2659fe21e093c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 |
| filingDate | 2010-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50dc3c4fe719f00f08653c00c797287b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52e091121fc6c9417db4ecee9406bbd1 |
| publicationDate | 2016-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2560787-T3 |
| titleOfInvention | Methods for producing hydrocodone, hydromorphone or a derivative thereof |
| abstract | A method for preparing a compound of Formula III from a compound of Formula I: ** Formula ** comprising the method of contacting the compound of Formula I and a hydrazide reagent of Formula II in a first reaction mixture for at least 6 hours at a reaction temperature greater than 60 ° C and less than 110 ° C, to convert the compound of Formula I into the compound of Formula III, where: R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, allyl substituted or unsubstituted, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted acyl, substituted or unsubstituted formyl, hydroxyl, carboxy ester substituted or unsubstituted and substituted or unsubstituted carboxamide; R2 is selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted acyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted alkylsulfonyl, substituted carboxy ester or unsubstituted, substituted or unsubstituted carboxamide, substituted or unsubstituted alkylsilyl, substituted or unsubstituted heterocycloalkyl; R3 is selected from substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted acyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted carboxyter substituted, substituted or unsubstituted carboxamide, substituted or unsubstituted trialkylsilyl, substituted or unsubstituted heterocycloalkyl; R8 and R9 are independently selected from the group consisting of hydrogen, hydroxyl and substituted or unsubstituted hydrocarbyl or R8 and R9 together form a carbonyl group; R10, R11 and R14 are independently selected from the group consisting of hydrogen, substituted or unsubstituted hydrocarbyl, and a halogen and R15 is hydrogen; R16 is selected from the group consisting of hydrogen and substituted or unsubstituted hydrocarbyl; and R18 is a sulfonyl group having the formula R20-S (O) 2-, where R20 is p-tolyl and the hydrazide reagent of Formula II is p-toluene sulfonyl hydrazide. |
| priorityDate | 2009-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.