| abstract |
A compound of formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any relationship, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them, in which Ht is chosen from the series that consists of G is R71-OC (O) -; R1 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, CF3, cycloalkyl (C3-C7) -CsH2s-, Ar- CsH2s-, Ar-O, (C1-C6) alkyl -O- , (C1-C6) alkyl -S (O) m- and NC-; in which s is an integer chosen from the series consisting of 0, 1, 2 and 3; R2 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, CF3, (C1-C6) alkyl -O-, (C1-C6) alkyl-S (O) m- and NC-; R10 is chosen from the series consisting of R11; R11 is Ar; R30 is chosen from the series consisting of cycloalkyl (C3-C7) and R32-CuH2u-, in which u is an integer chosen from the series consisting of 0, 1, 2 and 3; R32 is chosen from the series consisting of phenyl and a 5-membered or 6-membered monocyclic aromatic heterocycle comprising one, two or three identical or different annular heteroatoms chosen from the series consisting of nitrogen, oxygen and sulfur and are linked via a annular carbon atom, in which the phenyl and heterocycle are all optionally substituted with one or more identical or different substituents chosen from the series consisting of halogen, (C1-C6) alkyl, cycloalkyl (C3-C7), HO- , (C1-C6) alkyl -O-, -O-CH2-O-, -O-CF2-O-, (C1-C6) alkyl -S (O) m-, H2N-S (O) 2-, (C1-C4) alkyl -NH-S (O) 2-, di ((C1-C4) alkyl) NS (O) 2-, H2N-, (C1-C6) alkyl -NH-, di (C1 (alkyl) - C6)) N-, (C1-C4) alkyl -C (O) -NH-, (C1-C4) alkyl -S (O) 2-NH- and NC-; R40 is chosen from the series consisting of hydrogen and (C1-C4) alkyl; R50 is chosen from the series consisting of hydrogen, (C1-C6) alkyl, HO- and (C1-C6) alkyl -O-; R60 is chosen from the series consisting of hydrogen and (C1-C6) alkyl; R71 is hydrogen; Ar, regardless of each of the other Ar groups, is selected from the series consisting of phenyl and a 5-membered or 6-membered monocyclic aromatic heterocycle comprising one, two or three identical or different annular heteroatoms chosen from the series consisting of in nitrogen, oxygen and sulfur and are linked via an annular carbon atom, in which the phenyl and the heterocycle are all optionally substituted with one or more identical or different substituents chosen from the series consisting of halogen, (C1-C6) alkyl ), (C1- C6) alkyl -O-, -O-CH2-O-, -O-CH2-CH2-O-, -O-CF2-O-, (C1-C6) alkyl -S (O) m -, H2N-S (O) 2-, CF3 and NC-; m, regardless of each of the other numbers m, is an integer chosen from the series consisting of 0, 1 and 2; wherein all cycloalkyl groups, independently of one another, are optionally substituted with one or more identical or different substituents chosen from the series consisting of fluorine and (C1-C4) alkyl; wherein all alkyl groups, CsH2s, CuH2u, (CH2) x and (CH2) and, independently of each other, and independently of any other substituents, are optionally substituted with one or more fluorine substituents. |