http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2559679-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2007-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed0e7cf4fde1d4b4f7e8fd194f1ade13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abef2506527e5cd487c20d51d01ffcf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3977c68b1bbd411a7f8478d59ca0a3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e84aaa0b28189be692f47453a9c53203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb832b51e7f9533f18c81a2307da4fb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b937a9897f4424246449a4e7cc2f267 |
| publicationDate | 2016-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2559679-T3 |
| titleOfInvention | Pyrazoloquinazolinones as PARP inhibitors |
| abstract | A compound of Formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, in which R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkynyl , cyano, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, nitro, NRARB, and (NRARB) carbonyl; X is heterocycloalkyl, where X is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents, Z, independently selected from the group consisting of alkyl, alkenyl, alkynyl, nitro, -CN, halogen, haloalkyl , alkoxy, alkylcarbonyl, alkylcarbonylalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aryl, arylalkyl, arylalkoxy, arylalkoxycarbonyl, arylalkylcarbonyl, carboxy, carboxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkylcarbonyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heteroarilcarbonilalquilo, heterocycle, heterocycloalkyl, heterocycloalkylcarbonyl, heterocyclocarbonyl , heterocyclocarbonylalkyl, hydroxy, hydroxyalkyl, NRCRD, (NRCRD) alkyl, (NRCRD) carbonyl, (NRCRD) carbonylalkyl, and oxo; wherein the aryl and heteroaryl residues of Z are independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, formyl, halogen, and haloalkyl, and the heterocycle and cycloalkyl residues Z's are independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, oxo, formyl, halogen, and haloalkyl; RC and RD are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alquilcarboniloxialquilcarbonilo, arylcarbonyl, aryl, arylalkyl, arylalkylcarbonyl, carboxyalkyl, carboxyalkylcarbonyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkylcarbonyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocyclealkyl, heterocyclecarbonyl , heterocycloalkylcarbonyl, (NRARB) alkyl, and (NRARB) alkylcarbonyl; wherein if RC or RD are aryl, arylalkyl, arylalkylcarbonyl, arylcarbonyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocycloalkyl, heterocyclocarbonyl, or heterocycloalkylcarbonyl, then RC or RD may be unsubstituted or substituted, 3, 4, or 5 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, nitro, -CN, halogen, haloalkyl, oxo, alkoxy, alkylcarbonyl, alkylcarbonylalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aryl, arylalkyl, arylalkyl arylalkylcarbonyl, and arylalkoxycarbonyl; wherein RA and RB are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, and alkylcarbonyl; and n is 1. |
| priorityDate | 2006-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 397.