http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2558839-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b70512b2076a2759fccaecf9fe962d5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2007-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b7192aeac95c07b21c69c7b269dfa2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23dcbc1fdd68779c042bf1577a81d264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d57944cfcc2af9083d5767277c1e896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f842f6ce5171d1c88e7b328264c91ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f46242ef92a8c298856a1d1dd015ae9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89ef461c4bcc72ee18bea1af445afbc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_965f154cee3281aa69f371f744ef9907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bd6ea84e71bc03f83dc6cb7534ba443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c63b66856063f5521d6c6ab4684d059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_638da7b8d406daed2ab5d9dfdb22adbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a5998ec4fe025cafb1ab308d82db45c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3970b173c1e0d2975fb8d25ca2fd9802 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1111d47f612c55780778f10119d37a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91c60853517168412a383734ff2fbead http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0077d4032f3b8c2741e981879f3135a |
| publicationDate | 2016-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2558839-T3 |
| titleOfInvention | Tricyclic amines derivatives as protein tyrosine kinase inhibitors |
| abstract | A compound of formula (I): **Formula** where X1 is carbon; X2 and X3 are each independently selected from carbon or nitrogen, such that at least one of X1-X3 represents nitrogen; X4 represents CR3 or nitrogen; X5 represents CR6, nitrogen or C>=O; provided that not more than three of X1-X5 represent nitrogen; represents a single or double bond, such that at least one bond within the 5-membered ring system is a double bond; R3 represents hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-6 cycloalkyl, C3-6 chloroalkenyl, cyano, haloC1-6 alkyl, haloC1-6 alkoxy, or >=O ; A represents a phenyl or pyridinyl group which may be optionally substituted by one or more groups (eg 1, 2 or 3) Ra; B represents a -V-carboxylic group or a -W-heterocyclyl group wherein said carboxylic and heterocyclic groups may be optionally substituted by one or more Ra groups (eg 1, 2 or 3); R2 represents an aryl or heterocyclyl group wherein said aryl and heterocyclyl groups may be optionally substituted by one or more Rb groups; R6 represents halogen, hydrogen, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, -C≡N, C3-8 cycloalkyl, C3-8 cycloalkenyl, -NHSO2Rw, -CH>=N- ORw, an aryl or heterocyclyl group, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl and heterocyclyl groups may be optionally substituted by one or more Rb groups; Re, Rf and Rw independently represent hydrogen or C1-6 alkyl; Ra represents halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, -ORx, -(CH2)n-OC1-6 alkyl, -O-(CH2) groups n-ORx, haloC1-6 alkyl, haloC1-6 alkoxy, C1-6 alkanol, >=O, >=S, nitro, Si(Rx)4, -(CH2)s-CN, -SRx, -SO-Rx , -SO2-Rx, - CORx, -(CRxRy)s-COORz, -(CH2)s-CONRxRy, -(CH2)s-NRxRy, -(CH2)s-NRxCORy, -(CH2)s- NRxSO2-Ry , -(CH2)s-NH-SO2-NRxRy, -OCONRxRy, -(CH2)s-NRxCO2Ry, -O-(CH2)s-CRxRy-(CH2)t-ORz or -(CH2)s-SO2NRxRy; Rx, Ry and Rz independently represent hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkanol, hydroxy, C1-6 alkoxy, haloC1-6 alkyl, -CO-(CH2)n-C1 -6 alkoxy, C3-8 cycloalkyl or C3-8 cycloalkenyl; R1 and Rb independently represent a Ra group or a -Y-carbocyclyl or -Z-heterocyclyl group wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more Ra groups (eg 1, 2 or 3); V and W independently represent a bond or a -(CReRf)n- group; Y and Z independently represent a bond, -CO-(CH2)s-, -COO-, -(CH2)n-, -NRx-(CH2)n-, -(CH2)n-NRx-, -CONRx-, -NRxCO-, -SO2NRx-, -NRxSO2-, -NRxCONRy-, -NRxCSNRy- -O-(CH2)s-, -(CH2)sO-, -S-, -SO- or -(CH2)s-SO2 - ; n represents an integer from 1-4; s and t independently represent an integer from 0-4; q represents an integer from 0-2; or a pharmaceutically acceptable salt or solvate thereof. |
| priorityDate | 2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 460.