| abstract |
A GLP-1 analog of formula II: ** Formula ** wherein Xaa7 is L-histidine; Xaa8 is Aib; Xaa16 is Val; Xaa18 is Ser; Xaa19 is Tyr; Xaa20 is Leu; Xaa22 is Gly or Aib; Xaa23 is Gln; Xaa25 is Ala; Xaa27 is Glu; Xaa30 is Ala; Xaa33 is Val; Xaa34 is Arg; Xaa35 is Gly; Xaa36 is Arg; Xaa37 is Gly; Xaa38 is absent; and where U is a spacer selected from ** Formula ** where n is 12, 13, 14, 15, 16, 17 or 18, I is 12, 13, 14, 15, 16, 17 or 18, m is 0, 1, 2, 3, 4, 5 or 6, s is 0, 1, 2 or 3, p is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,18, 19, 20, 21, 22 or 23; and where B is an acid group selected from ** Formula ** |