http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2556752-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c509c10f7993bf4185abf29e4bf8d50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2009-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fb73d0ec9c355be4a717fcc20bc4a4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f57e828e751984017fce48324a8e7b01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8c49f7adda20b0a2eb088919ebdd187 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfc184f1f9389efa79b90f1d30235159 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7149a31715fe28c05488b35c72eb4299 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58a263e15ccb0116e7341a2382b5ce72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8467e9b3cf488b3607c8a9995e27a669 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_802fcf70599ea20d4a00a6c4e44193eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3bb0b081ffea0b99142309343cc3274 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2630c57d0add9e4f30ab729959d06017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27cc9cab03aa0cf6c9ca7e052d74112c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10bf3c5fc42cff0b1e0f4bbd4fb757d3 |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2556752-T3 |
| titleOfInvention | Cannabinoid receptor ligands |
| abstract | A compound according to formula (I), or a pharmaceutically acceptable salt or solvate thereof X4 is O or N (Rbx); wherein Rbx is hydrogen, alkyl, haloalkyl, alkoxyalkyl, -C (O) O (alkyl), monocyclic cycloalkyl, - (CR1cR1d) q3- (monocyclic cycloalkyl), or haloalkoxyalkyl; and A1 is -N (Rb) C (O) Ra, -N (Rb) C (O) ORd, -N (Rb) C (O) N (Rb), -N (Rb) (Rc), or - N> = C (Rp) (Rq); or X4 and A1 together are N> = N (Rcx); A3 is C (O) Rh, -S (O) 2Rc, -C (O) N (Rh) 2, -C (S) N (Rh) 2, -S (O) 2N (Rh) 2, -C (> = NORh) Rh, -N (Rh) C (O) Rh, -N (Rh) C (O) ORe, -N (Rh) S (O) 2Rc, -N (Rh) C (O) N (Rh) 2, -N (Rh) S (O) 2N (Rh) 2, -CN, -ORh, or -N (Rh) 2; Ra and Rc are each, at each occurrence independently hydrogen, alkyl, haloalkyl, - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d; Rb is each, at each occurrence independently hydrogen, alkyl, haloalkyl, alkoxyalkyl, monocyclic cycloalkyl, - (CR1cCR1d) q3- (monocyclic cycloalkyl), or haloalkoxyalkyl; Rd, at each occurrence is independently alkyl, haloalkyl, - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d; Rcx is alkyl, haloalkyl, - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d; Rp is hydrogen, alkyl, haloalkyl, - (CR1aR1b) q3-A3, -C (O) ORd, -C (O) Rd, G1d, or - (CR1aR1b) q3-G1d; Rq is hydrogen, alkyl, haloalkyl, -N (Rb) Rc), - (CR1aR1b) q3-A3, G1d, or - (CR1aR1b) q3-G1d; or Rp and Rq, together with the carbon atom to which they are attached, form a monocyclic 5, 6, 7, or 8-membered ring, optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting in oxo, alkyl, haloalkyl, and halogen; A5 represents the formula (a), (b) or (c) G1d, at each occurrence, it is independently a monocyclic heterocycle, a monocyclic heteroaryl, a phenyl, a monocyclic cycloalkyl, or a monocyclic cycloalkenyl; wherein G1d is optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of -N (Rh) 2, -CN, oxo, alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, and OH; Re, at each occurrence, is independently C1-C4 alkyl, C1-C4 haloalkyl, monocyclic cycloalkyl, monocyclic heterocycle, or - (CR1cCR1d) q3- (monocyclic cycloalkyl); Rf, at each occurrence, is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, - (CR1cR1d) q3-ORh, monocyclic heterocycle, monocyclic cycloalkyl, or - (CR1cR1d) q3- (monocyclic cycloalkyl); Rh, at each occurrence, is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, monocyclic cycloalkyl, or - (CR1cR1d) q3- (monocyclic cycloalkyl); R21, R22 and R23 are each independently alkyl, alkenyl, alkynyl, haloalkyl, - (CR2aR2b) q4-OH, - (CR2aR2b) q4-O-alkyl, - (CR2aR2b) q4-O-haloalkyl, - (CR2aR2b) q4 -CO-G2a, - (CR2aR2b) q4-O- (CR2cR2d) q3-G2a, - (CR2aR2b) q5- C (O) -Ra, - (CR2aR2b) q5-C (> = N-ORf) Ra, - (CR2aR2b) q5-SO2-Rd, (CR2aR2b) q5-G2b, - (CR2aR2b) q5-C (O) N (Rb) (Rc), or - (CR2aR2b) q5-CN; G2a is independently at each occurrence cycloalkyl, heterocycle, aryl, or heteroaryl; G1b is a monocyclic ring selected from the group consisting of cycloalkyl, cycloalkenyl, thienyl, phenyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, and heterocycle; wherein the heterocycle contains zero or a double bond, one or two oxygen, and zero or a nitrogen as ring atoms; two non-adjacent atoms of said heterocyclic ring may optionally be connected by an alkenylene bridge of 2, 3, or 4 carbon atoms, or optionally connected by an alkylene bridge of 1, 2, 3, or 4 carbon atoms; each G2b ring is optionally fused with a monocyclic ring selected from the group consisting of benzo, cycloalkyl, cycloalkenyl, heterocycle and heteroaryl; G2a and G2b are each independently unsubstituted or substituted at each occurrence with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of oxo, alkyl, halogen, -OH, alkoxy, haloalkoxy, and haloalkyl; X1 is O or S; X2 is N (R10) wherein R10 is alkyl, alkoxyalkyl, haloalkoxyalkyl, or haloalkyl; R3, R4, R5, R6, R7, R8 and R9 are each independently G3, hydrogen, alkyl, alkenyl, alkynyl, -NO2, -CN, halogen, -ORh, -N (Rh) 2, -C (O) Rh, -C (O) O (Rh), haloalkyl, - (CR3aR3b) q6-ORh, - (CR3aR3b) q6-N (Rh) 2, - (CR3aR3b) q6- C (O) Rh, or - (CR3aR3b ) q6-C (O) O (Rh); G3, at each occurrence, is independently cycloalkyl, cycloalkenyl, aryl, heterocycle, or heteroaryl wherein each G3 is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from the group consisting of C1-C4 alkyl, C2 alkenyl -C4, C2-C4 alkynyl, halogen, C1-C4 haloalkyl,> = N-CN,> = N-ORh, -CN, oxo, -ORh, -OC (O) Rh, -OC (O) N (Rh ) 2, -S (O) 2Re, -S (O) 2N (Rh) 2, -C (O) Rh, -C (O) ORh, -C (O) N (Rh) 2, -N (Rh ) 2, -N (Rh) C (O) Rh, -N (Rh) S (O) 2Re, -N (Rh) C (O) O (Re), and -N (Rh) C (O) N (Rh) 2; R1a, at each occurrence, is independently hydrogen, halogen, C1-C4 alkyl or C1-C4 haloalkyl; R1b, at each occurrence, is independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 haloalkyl, -ORh, -N (Rh) 2, -N (Rh) C (O) Rh, -N (Rh) C (O) ORe; or -N (Rh) S (O) 2Re; R1c, R1d, R2a, R2b, R2c, R2d, R3a and R3b, at each occurrence, are each independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 haloalkyl; Rx at each occurrence is independently C1-C4 alkyl, halogen, C1-C4 haloalkyl or -CN; q4, at each occurrence, is independently 2, 3, 4, or 5; q3, at each occurrence, is 1, 2 or, 3; q5 and q6, at each occurrence, are each independently 1, 2, 3, 4, 5, or 6; z is 0, 1, 2, 3, or 4; and the monocyclic cycloalkyl and the monocyclic heterocycle, as a substituent or as part of a substituent, of Rb, Rb, Re, Rf, and Rh, are each independently unsubstituted or substituted at each occurrence with 1, 2, 3, or 4 substituents independently selected from the group consisting of oxo, C1-C4 alkyl, halogen, OH, C1-C4 alkoxy, C1-C4 haloalkoxy, and C1-C4 haloalkyl, |
| priorityDate | 2008-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 826.