http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2555968-T3

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fde3c3de1cc185d3f5c632d20b5f7382
classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-78
filingDate 2009-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd344b0d02b8e1b0aaab88e52fe461a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83020ee2708247d396406b6550e27e0d
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publicationDate 2016-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2555968-T3
titleOfInvention Procedure for the production of cyclopropane derivatives
abstract A process for the preparation of a cyclopropane derivative of Formula (I),**Formula** by reacting an olefin of Formula (II),**Formula** with a carbene of formula: CR1R2, in a reaction vessel , optionally in the presence of a solvent, where R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, -C(O)R7 or -NR8 2 ; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, -C(O)R9 or -NR10 2, -SR11, -S(O)R11, or -SO2R11, or R3 and R6 are defined as above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl, or -NR10 2; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl, or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6-alkyl, C1-C6-alkoxy, aryl, aryloxy, or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, -C(O)R12; R11 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, carbocyclyl, or heterocyclyl; and R12 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, or aryloxy, in the presence of metallic copper or copper oxide, where the process is a continuous process.
priorityDate 2008-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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