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filingDate 2012-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_427e053b9f86d0d44f6e106315718108
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publicationDate 2015-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2554459-T3
titleOfInvention Combined therapy with interferon beta and andrographolides for multiple sclerosis
abstract A compound of Formula I: ** Formula ** wherein R1 is selected from the group consisting of hydrogen, alkyl, or hydroxyl, R2 is selected from the group consisting of hydroxyalkyl or alkyl-O-L1, where L1 is a residue of carbohydrate, R3 is selected from the group consisting of hydrogen or hydroxyl, X is selected from the group consisting of C (> = CH2), CH (OH), or a residue of spirooxirane-2. Z is selected from the group consisting of CH2, CH (OH), or C (> = O), and R4 is selected from the group consisting of an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is a 3- moiety optionally substituted furanyl or an optionally substituted 3-fur-3-enyl moiety, or a pharmaceutically acceptable salt, ester, ether or prodrug thereof, for use in treating a demyelinating disease in a human patient wherein said demyelinating disease comprises the multiple sclerosis and where said human patient is treated with beta interferon.
priorityDate 2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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