http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2554375-T3
Outgoing Links
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|---|---|
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2009-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3abf649734a7198adbd410cdf92ad6d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5637fc7d923173c68020ac6534c3bd6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3354a785562b6750592e2bde0c86b8fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7affa2567cd8b3b778be5107368e892 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9651a5280cdca7f656e8d1b88b349cae |
| publicationDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2554375-T3 |
| titleOfInvention | MLK Inhibitors and Methods of Use |
| abstract | A compound having a structural Formula VI or VIII: ** Formula ** or a salt or prodrug thereof, wherein said prodrug is selected from a carboxylate ester, carbonate ester, half ester, phosphorus ester, nitro ester, ester of sulfate, sulfoxide, amide, carbamate, azo, phosphamide, glucoside, ether, acetal or ketal thereof; R3 is selected from lower cycloalkyl, phenyl and lower heteroaryl and wherein R3 is substituted with one or more substituents selected from halogen, hydroxy, lower amino, lower amido, lower phenylamido, lower phenylalkylamido, lower heterocycloalkyl, lower alkylheterocycloalkyl, C1-C3 alkoxy and C1-C3 alkyl, wherein two substituents may be linked together to form a five-, six-, or seven-membered fused carbocyclic or heterocyclic ring comprising zero to three heteroatoms; Y3 is selected from a bond and methyl; wherein the residue R14-Y4-R2 is selected from where u is an integer from 0 to 3; where Y4 is -CH2-; and wherein each R15 is independently selected from halogen, hydroxy, lower amino, C1-C3 alkoxy, and C1-C3 alkyl, and wherein R14 is selected from none and optionally substituted lower heterocycloalkyl, wherein said optional substituents are selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower heteroalkyl, lower heterocycloalkyl, lower haloalkyl, lower cycloalkyl, phenyl, aryl, aryloxy, lower alkoxy, lower haloalkoxy, oxo, lower acyloxy, carboxyl, lower alkylcarbonyl, carboxy ester lower, lower carboxamido, halogen, hydroxy, amino, lower alkylamino, arylamino, amido, nitro, thiol, lower alkylthio, lower haloalkylthio, sulfonate, and sulfonic acid, wherein the term "lower" when not specifically defined otherwise means that contains 1 to 6 carbon atoms inclusive; wherein said lower cycloalkyl is a monocyclic cycloalkyl having between three and six ring members, which is optionally unsaturated; wherein said lower heteroaryl is either 1) monocyclic heteroaryl comprising five or six members in the ring, of which between one and four may be heteroatoms chosen from O, S and N or 2) bicyclic heteroaryl wherein each of the fused rings comprise five or six members in the ring, comprising between them from one to four heteroatoms chosen from O, S and N; wherein said lower amino refers to -NRR ', wherein R and R' are independently selected from hydrogen, lower alkyl, and lower heteroalkyl, any of which may be optionally substituted, and wherein R and R 'may combine to form a five or six membered heterocycloalkyl, either of which may be optionally substituted; wherein said lower heterocycloalkyl is a monocyclic heterocycloalkyl having between three and six members in the ring, of which between one and four can be heteroatoms chosen from O, S and N; wherein said heteroalkyl refers to a stable straight or branched chain or cyclic hydrocarbon radical, or combinations thereof, fully saturated or containing 1 to 3 degrees of unsaturation, consisting of the indicated number of carbon atoms and one to three heteroatoms chosen from O, N and S and where the nitrogen and sulfur atoms can be optionally oxidized and the nitrogen heteroatom can be optionally quaternized. |
| priorityDate | 2008-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 447.