http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2554330-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed28439dbd8cf3f6f3efa434e9396330 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2005-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5447c771d3ec15ff92722f49b46aa0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_578f61cd31c3594a0e5111556869886f |
| publicationDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2554330-T3 |
| titleOfInvention | Quinazoline derivatives and therapeutic use thereof |
| abstract | A compound for use in the treatment of a hyperproliferative disorder, which is a compound of the formula: ** Formula ** in which: (R1) n is selected from 6-NHCH2R3, H, 6-nitro, 6-bromine, 6-iodine, 7-fluoro, 5-methyl and 6,7-diethoxy; and R3 is selected from the group consisting of -CH (CH3) 2 and Ar, where Ar is selected from (a) 4-substituted phenyl, where the 4-substituent is selected from -CH (CH3) 2, -OCH2Ph, -OCH2CH2CH3 and -Ph; (b) 3-substituted phenyl, where the 3-substituent is selected from methoxy, 4-chlorophenoxy, benzyloxy, 4-methoxyphenoxy, 4-methylphenoxy, 3-trifluoromethylphenoxy and methyl; (c) 2-substituted phenyl, where the 2-substituent is selected from methyl, nitro, and benzyloxy; (d) disubstituted phenyl selected from 2,4-dimethoxyphenyl, 2,6-dimethoxyphenyl, 2,5-dimethoxyphenyl, 3,5-dimethoxyphenyl, 2,5-dimethylphenyl and 3,4-ethylenedioxyphenyl; (e) pyridine-3-y '; and (f) naphthylene-1-yl, optionally substituted with methoxy at the 2-position; and (i) when (R1) n is 6-NHCH2R3, then R2 is selected from 3-bromophenyl, 3-chloro-4-fluorophenyl, and (ii) when (R1) n is 6-nitro, 6-bromine, 6-iodo, 7-fluoro or 5-methyl, then, R2 is selected from: (a) cyclohexyl; (b) a substituted phenyl, selected from 2,4,6-trimethylphenyl, 2-fluoro-4-chlorophenyl, 4-fluorophenyl and 2-chlorophenyl; (c) CH2Ar, where Ar is selected from naphthylene-1-yl; 2-trifluoromethylphenyl and 3-trifluoromethylphenyl; (d) (CH2) 2Ar, where Ar is selected from phenyl, 3-fluorophenyl and 4-fluorophenyl; (e) α-methylbenzyl; and (f) 4-phenylbutyl; (iii) when (R1) n is 6,7-diethoxy, then R2 is selected from: (a) (CH2) mAr, where, m is 1, 2 or 4 and, when m> = 1, Ar is selected from 2-chlorophenyl, 4-chlorophenyl, 2-fluorophenyl, 2-chloro-6-fluorophenyl, 3-trifluoromethylphenyl and 3,5-dimethoxyphenyl; or when m> = 2, then Ar is selected from phenyl and 3-fluorophenyl and when m > = 4, Ar is phenyl; and (b) α-methylbenzyl; and (iv) when (R1) n is H, then R2 is selected from: (a) cyclohexyl; (b) a substituted phenyl, selected from 2,4,6-trimethylphenyl, 2-fluoro-4-chlorophenyl, 4-fluorophenyl and 2-chlorophenyl; (c) CH2Ar, where Ar is selected from naphthylene-1-yl; 2-trifluoromethylphenyl and 3-trifluoromethylphenyl; (d) (CH2) 2Ar, where Ar is selected from phenyl, 3-fluorophenyl and 4-fluorophenyl; and (e) 4-phenylbutyl or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2004-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.