abstract |
A heterocyclic compound represented by formula (1) or a salt thereof: where m> = 2, 1> = 1 and n> = 1; X -CH2-; R1 represents hydrogen, a C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group, a protecting group selected from substituted or unsubstituted C1-C6 alkanoyl groups, phthaloyl, C1-C6 alkoxycarbonyl, substituted or unsubstituted aralkyloxycarbonyl, 9- fluorenylmethyloxycarbonyl, nitrophenylsulfenyl, aralkyl and C1-C6 alkylsilyl, or a tri-C1-C6 alkylsilyloxy-C1-C6 alkyl group; R2 and R3, which are the same or deferent, each independently represent hydrogen or a C1-C6 alkyl group; or R2 and R3 are linked to form a C3-C8 cyclo-alkyl group; and R4 represents any one of (1) a phenyl group, (2) an indolyl group, (3) a benzothienyl group, (4) a naphthyl group, (5) a benzofuryl group, (6) a quinolyl group, (7) an isoquinolyl group, (8) a pyridyl group, (9) a thienyl group, (10) a dihydrobenzoxazinyl group, (11) a dihydrobenzodioxynyl group, (12) a dihydroquinolyl group, (13) a chromanyl group, (14) a quinoxalinyl group, (15) a dihydroindenyl group, (16) a dihydrobenzofuryl group, (17) a benzodioxolyl group, (18) an indazolyl group, (19) a benzothiazolyl group, (20) an indolinyl group, (21) a group thienopyridyl, (22) a tetrahydrobenzazepinyl group, (23) a tetrahydrobenzodiazepinyl group, (24) a dihydrobenzodioxepinyl group, (25) a fluorenyl group, (26) a pyridazinyl group, (27) a tetrahydroquinolyl group, (28) a carbazolyl group , (29) a phenanthryl group, (30) a dihydroacenaphthylenyl group, (31) a pyrrolopyridyl group, (32) an antryl group, (33) a benzodioxynyl group, (34) a pyrrolidinyl group, (35) a pyrazolyl group, (36) an oxadiazolyl group, (37) a pyrimidinyl group, (38) a tetrahydronaphthyl group, (39) a dihydroquinazolinyl group, (40) a benzoxazolyl group, (41) a group thiazolyl, (42) a quinazolinyl group, (43) a phthalazinyl group, (44) a pyrazinyl group, and (45) a chromenyl group, where these aromatic or heterocyclic groups may have one or more substituents selected from (1-1) a halogen atom. |