http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2553143-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-74 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a77f44938b9efa14bc91fadd50496a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d146b36eb148b06f5a7dbe48035f1b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a4de3d00d82805d4260838e800d86fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5a787ee6f62374e117851fd3c25a87c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a03e05c8948cf07c898c46bef35a811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92a1fef763568cc14e84883780794304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb945bb5404c9ff8c796f5707bc068bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bdb069dd52b62841fe7c1a1d9194046 |
| publicationDate | 2015-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2553143-T3 |
| titleOfInvention | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| abstract | A compound, or a therapeutically acceptable salt thereof, wherein the compound is selected from the group consisting of: 4- (4- {acetyl [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3 , 1,1] hept-3-yl] amino} piperidin-1-yl) -N - ({4- [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; 4- (4- {benzyl [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept-3-yl] amino} piperidin-1-yl) -N- ( {4- [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -3 '- {[(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept -3-yl] amino} biphenyl-4-carboxamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- (4 - {(phenylacetyl) [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3, 1,1] hept-3-yl] amino} piperidin-1-yl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4 '- {[(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept -3-yl] amino} biphenyl-4-carboxamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4 '- {(3-phenylpropyl) [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3, 1,1] hept-3-yl] amino} biphenyl-4-carboxamide; 4- (4 - {[(1R, 5R) -3-bromo-5-methylamantan-1-yl] methyl} piperazin-1-yl) -N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl } sulfonyl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- (4 - {[3,5-dimethylamantan-1-yl] methyl} piperazin-1- yl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2 - [(1R, 4R) -1,7,7- trimethylbicyclo [2,2,1] hept-2-en-2-yl] benzyl} piperazin-1-yl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2-octahydro-1H-4,7-methanoinden-5- ylamino ] benzyl} piperazin-1-yl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- [4- (2 - {[(1R, 4R, 6S) -5.5 , 6- trimethylbicyclo [2,2,1] hept-2-yl] amino} benzyl) piperazin-1-yl] benzamide; 4- [4- (2 - {[(1R, 5S) -6,6-dimethylbicyclo [3,1,1] hept-2-yl] amino} benzyl) piperazin-1-yl] -N - ({3 -nitro-4 - [(tetrahydro-2Hpiran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; 4- (4 - {[(1R, 5R) -2- (4-chlorophenyl) -6,6-dimethylbicyclo [3,1,1] hept-2-en-3-yl] methyl} piperazin-1-yl ) -N - ({4- [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; 4- {4 - [(2 - {[adamantan-2-ylmethyl] amino} -5,5-dimethylcyclohexyl) methyl] piperazin-1-yl} -N - ({3-nitro-4 - [(tetrahydro-2Hpiran - 4-ylmethyl) amino] phenyl} sulfonyl) benzamide; 4- {4 - [(5,5-dimethyl-2 - {[(1R, 2S, 3S, 5S) -2,6,6-trimethylbicyclo [3,1,1] hept-3-yl] amino} cyclohexyl ) methyl] piperazin-1-yl} - N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; 4- {4- [2- (3-azabicyclo [3,2,2] non-3-yl) -5-nitrobenzyl] piperazin-l-yl} -N - ({3-nitro-4 - [(tetrahydro -2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; 4- (4- {2- [2,3,3a, 4,7,7a-hexahydro-1H-4,7-methanoinden-5-yl] benzyl} piperazin-1-yl) -N - ({3- nitro-4 - [(tetrahydro-2Hpiran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; 1- [adamantan-1-yl] -4- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) carbamoyl ] phenyl} piperazin-1-yl) methyl] phenyl} -N, N-diphenyl-1 H-pyrazol-3-carboxamide; 4- (4-12- [2- (adamantan-1-yl) -6-methylimidazo [1,2-a] pyridin-8-yl] benzyl} piperazin-1-yl) -N - ({3-nitro -4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; N- (adamantan-2-yl) -6-methyl-8- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl } sulfonyl) carbamoyl] phenyl} piperazin-1-yl) methyl] phenyl} imidazo [1,2-a] pyridin-2-carboxamide; 4- (4- {2 - [(1R, 5S) -6,6-dimethylbicyclo [3,1,1] hept-2-en-2-yl] benzyl} piperazin-1-yl) -N - ({ 3-nitro-4 - [(tetrahydro-2Hpiran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2- [5,5,6-trimethylbicyclo [2,2, 1] hept-2-en-2-yl] benzyl} piperazin-1-yl) benzamide; N-benzyl-7,7-dimethyl-2- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) carbamoyl ] phenyl} piperazin-1-yl) methyl] phenyl} bicyclo [2,2,1] hept-2-ene-1-carboxamide; 4- [4- (2 - {[(1R, 5S) -8-methyl-8-azabicyclo [3,2,1] oct-3-yl] amino} benzyl) piperazin-1-yl] -N- ( {3-nitro-4 - [(tetrahydro-2Hpiran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- [4- (2 - {[(1R, 2S, 3S, 5S) -2 , 6,6-trimethylbicyclo [3,1,1] hept-3-yl] amino} benzyl) piperazin-1-yl] benzamide; 4- (4- {2- [3-Azabicyclo [3,2,2] non-3-yl] benzyl} piperazin-1-yl) -N - ({3-nitro-4 - [(tetrahydro-2H- piran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2- [tricycle [4,3,1,13,8]] undec-4-en-4- yl] benzyl} piperazin-1-yl) benzamide; 7,7-dimethyl-2- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) carbamoyl] phenyl} piperazin - 1-yl) methyl] phenyl} -N-phenylbicyclo [2,2,1] hept-2-ene-1-carboxamide; 7,7-dimethyl-2- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) carbamoyl] phenyl} piperazin - 1-yl) methyl] phenyl} -N - [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept-3-yl] bicyclo [2,2,1 ] hept-2-eno-1-carboxamide; N- (adamantan-1-ylmethyl) -7,7-dimethyl-2- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino) ] phenyl} sulfonyl) carbamoyl] phenyl} piperazin-1-yl) methyl] phenyl} bicyclo [2,2,1] hept-2-eno-1-carboxamide; N-cyclopropyl-7,7-dimethyl-2- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) carbamoyl ] phenyl} piperazin-1-yl) methyl] phenyl} bicyclo [2,2,1] hept-2-ene-1-carboxamide; 7,7-dimethyl-2- {2 - [(4- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4- ylmethyl) amino] phenyl} sulfonyl) carbamoyl] phenyl} acid} piperazin-1-yl) methyl] phenyl} bicyclo [2,2,1] hept-2-eno-1-carboxylic; 4- [4- (2- {5- [8-azabicyclo [3,2,1] oct-8-ylmethyl-2-thienyl} benzyl) piperazin-1-y1] -N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- (4 - {(3-phenylpropanoyl) [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [ 3,1,1] hept-3-yl] amino} piperidin-1-yl) benzamide; 4- {4- [adamantan-1-ylmethyl] piperazin-1-yl} -N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; 4- (4- {2- [adamantan-1-yl] -2-oxoethyl} piperazin-1-yl) -N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- {4 - [(1S, 2S, 3S, 5R) -2,6,6-trimethylbicyclo [3,1,1] hept-3- yl] piperazin-1-yl} benzamide; 4- {4- [adamantan-l-yl] piperazin-l-yl} -N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4- {4- [3,5-dimethylamantan-1-yl] piperazin-1-yl} benzamide; 4- (4- {2- [adamantan-1-yl] ethyl} piperazin-1-yl) -N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) benzamide; N - ({4 - [(cyclohexylmethyl) amino] -3-nitrophenyl} sulfonyl) -4 '- ({(3-phenylpropanoyl) [(1S, 2S, 3S, 5S) -2,6,6-trimethylbicyclo [3 , 1,1] hept-3-yl] amino} methyl) biphenyl-4-carboxamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2 - [(R, 4R) -1,7,7- trimethylbicyclo [2,2,1] hept-2-en-2-yl] benzylidene} piperidin-1-yl) benzamide; 4- [4- (2- {5- [4- (adamantan-1-yl) -1,3-thiazol-2-yl] -2-thienyl} benzyl) piperazin-1-yl] -N - ({ 3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; 1- [adamantan-1-yl] -4- {2 - [(1- {4 - [({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) carbamoyl ] phenyl} piperidin-4-ylidene) methyl] phenyl} -N, N-diphenyl-1H-pyrazol-3-carboxamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- (4- {2- [octahydro-1H-4,7-methanoinden-5- il (3- phenylpropanoyl) amino] benzyl} piperazin-1-yl) benzamide; 4- [4- (2- {5- [8-azabicyclo [3,2,1] oct-8-ylmethyl] -2-thienyl} benzylidene) piperidin-1-yl] -N - ({3-nitro- 4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- [4- (4 - {[(1S, 2S, 3S, 5R) -2 , 6,6-trimethylbicyclo [3,1,1] hept-3-yl] amino} benzylidene) piperidin-1-yl] benzamide; N - ({3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -4- [4- (3 - {[(1S, 2S, 3S, 5R) -2 , 6,6-trimethylbicyclo [3,1,1] hept-3-yl] amino} benzylidene) piperidin-1-yl] benzamide; and 4- [4- (2- {5- [4- (adamantan-1-yl) -1,3-thiazol-2-yl] -2-thienyl} benzylidene) piperidin-1-yl] -N- ( {3-nitro-4 - [(tetrahydro-2Hpiran-4-ylmethyl) amino] phenyl} sulfonyl) benzamide. |
| priorityDate | 2010-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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