http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2552667-T3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c6ea50b6d998b67cf8e14724fa9f9b4 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate | 2007-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed9e853deeb907108d3137620b2f257d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c7a904f14d4df0d6cbb9d0ebf31bdc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a6f8bab9f64df13b69047a228849691 |
publicationDate | 2015-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2552667-T3 |
titleOfInvention | T cell vaccine |
abstract | A method of preparing a T-cell vaccine, comprising: (a) providing a sample comprising T cells isolated from a patient; (b) contacting the T cells with patient-specific peptide mixtures, whereby the self-reactive T cells are activated; (c) expand activated autoreactive T cells; and (d) attenuate the autoreactive T cells, so that the T cells are incompetent for replication but still viable; in which the patient-specific peptide mixtures comprise peptide mixtures of MBP, PLP and MOG capable of stimulating self-reactive T cells with a stimulation index above 1.3, the stimulation index for each peptide mixture being calculated by comparing the incorporation of [3H] thymidine in a sample of patient T cells cultured in the presence of a peptide mixture comprising a part of the polypeptide, with the incorporation of [3H] thymidine in a sample of T cells cultured only in a control medium, which is expresses as the ratio of the average counts per minute of antigen aliquots / average counts per minute of the control aliquots, wherein each peptide in a mixture of peptides is 8-20 amino acids and comprises a sequence that overlaps 4- 19 amino acids with another peptide from the peptide mixture. |
priorityDate | 2006-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.