| abstract |
A compound for use in the treatment of ocular inflammatory disorders or inflammatory diseases of the skin having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof, ** formula ** wherein R1 is H or C1-6 alkyl substituted or unsubstituted; R2 is H or C1-6 substituted or unsubstituted alkyl; R3 is N or C-R7; R4 is N or C-R8; R5 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C3-8 cycloalkenyl, or is substituted or unsubstituted C6-10 aryl; R6 is 2-benzofuran, 2-thienyl, 5-chloro-2-thienyl, 4,5-dichloro-2-thienyl, 4-chloro-3-methylphenyl, or 4-chloro-3-trifluoromethylphenyl; R15 is N or C-R16; R17 is N or C-R18; R7 is H, substituted or unsubstituted C1-6 alkyl, halogen, -O-C1-6 alkyl, CN, C2-6 alkenyl, C2-6 alkynyl, C (O) R9, NR10R11 or hydroxyl; R8 is H, substituted or unsubstituted C1-6 alkyl, halogen, -O-C1-6 alkyl, CN, C2-6 alkenyl, C2-6 alkynyl, C (O) R12, NR13R14 or hydroxyl; R16 is H, substituted or unsubstituted C1-6 alkyl, halogen, -O-C1-6 alkyl, CN, C2-6 alkenyl, C2-6 alkynyl, C (O) R19, NR20R21 or hydroxyl; R18 is H, substituted or unsubstituted C1-6 alkyl, halogen, -O-C1-6 alkyl, CN, C2-6 alkenyl, C2-6 alkynyl, C (O) R22, NR23R24 or hydroxyl; R9 is H or C1-6 substituted or unsubstituted alkyl; R10 is H or C1-6 substituted or unsubstituted alkyl; R11 is H or C1-6 alkyl substituted or unsubstituted; R12 is H or C1-6 substituted or unsubstituted alkyl; R13 is H or C1-6 substituted or unsubstituted alkyl; R14 is H or C1-6 substituted or unsubstituted alkyl; R19 is H or C1-6 substituted or unsubstituted alkyl; R20 is H or substituted or unsubstituted C1-6 alkyl; |