| abstract |
Anti-TNF-alpha polypeptide comprising at least one anti-TNF-alpha single domain antibody comprising (a) a sequence represented by SEQ ID NO: 1, or (b) a homologous sequence having a sequence identity of more 85% with the original sequence represented by SEQ ID NO: 1; wherein said homologous sequence contains the hydrophobic FR2 residues normally found in conventional antibodies of human origin and an arginine residue at position 103 (numbering according to Kabat). |