| abstract |
A compound according to formula I: ** Formula ** where Rx is CN, Cl, Br, NO2 or Rx1; Ry is CH3, CF3, or halogen; Rz is hydrogen or optionally C1-3 alkyl, C2-3 alkenyl, C1-3 hydroxyalkyl, C1-3 haloalkyl, NO2, NH2, OMe, halogen or OH; or Ry and Rz together form ** Formula ** where Ry 'is optionally a substituent selected from the group consisting of halogen, C1-3alkyl, halo C1-3alkyl and OH; Rx1 is a 5-membered heteroaryl, said heteroaryl being selected from ** Formula ** R 'is hydrogen or optionally C1-C2 alkyl, CF3 or halogen; or Rx and Ry together with the phenyl group to which they are attached form a 5-membered aromatic ring selected from: ** Formula ** wherein each R "is independently hydrogen or optionally CF3 or C1-C2 alkyl; P1 is hydrogen or a group selected from: an alkyl acyl group containing up to 20 carbons, an aryl acyl group containing up to 18 carbons, an alkyl ether group containing up to 12 carbons, sulfate or phosphate; Ra and Rb are each independently selected from hydrogen or C1-C3 alkyl; and X is CH2, O or NRc; wherein Rc is hydrogen or C1-C3 alkyl; or a pharmaceutically acceptable salt thereof. |