abstract |
Compound having the structure: ** Formula ** in which: R1 is H, or a C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl which is unsubstituted or substituted with at least one hydroxyl group; and R2 is H, or a C1-C3 alkyl; or R1 and R2 form a C3-C6 heterocyclic ring with the nitrogen attached to said R1 and R2; R3 is ** Formula ** or in which: R4 is H, or a C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl; R5 is a C1-C6 alkyl, C1-C6 alkoxy or C2-C6 alkyl ether which is unsubstituted or substituted with one or more of hydroxyl, phenyl, phenyloxy or fluorine, or R5 is NR7R8 or C (O) NR7R8 in which R7 and R8 are independently selected from H, a C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl group; R6 is H, or a C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl or C3-C6 cycloalkenyl group; and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof. |