| abstract |
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein: R1 represents ** Formula ** or ** Formula ** R2 represents H, C 1-8 alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, C 1-4 alkylaryl, C 1-4 alkylheteroaryl, C 1-4 alkylcarbocyclyl or C 1-4 alkylheterocyclyl; wherein any of the aforementioned aryl or heteroaryl groups may be substituted by one or more groups selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1- thioalkyl 6, -SO-C1-4 alkyl, -SO2-C1-4 alkyl, C1-6 alkoxy, -O3-8 cycloalkyl, C3-8 cycloalkyl, -SO2-C3-8 cycloalkyl, -SO-C3-6 cycloalkyl, C3-6 alkenyloxy, C3-6 alkynyloxy, -C (O) -C 1-6 alkyl, -C (O) O-C1-6 alkyl, C1- alkoxy 6-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkoxy, nitro, halogen, C 1-6 haloalkyl, C 1-6 haloalkoxy, cyano, hydroxyl, -C (O) OH, - NH2, -NH-C1-4 alkyl, -N (C1-4 alkyl) (C1-4 alkyl), -N (C1-4 alkyl) (C1-4 alkyl) -N (C1 alkyl -4) (C1-4 alkyl), C1-4-N- alkyl (C1-4 alkyl) (C1-4 alkyl), C1-4-N alkoxy (C1-4 alkyl) (alkyl C1-4), -N (C3-8 cycloalkyl) (C3-8 cycloalkyl), -N (C1-6 alkyl-C1-6 alkoxy) (C1-6 alkyl-C1-6 alkoxy ), -C (O) N (C1-4 alkyl) (C1-4 alkyl), -C (O) NH2, -C (O) NH (C1-4 alkyl) and C (O) NH (cycloalkyl of C3-10); and wherein any of the aforementioned carbocyclyl or heterocyclyl groups may be optionally substituted by one or more groups selected from C1-4 alkyl, oxo, halogen, -C (O) -C 1-6 alkyl, and C1 alkoxy -4; or R2 represents phenyl substituted by phenyl, phenyl substituted by a monocyclic heteroaryl group, phenyl substituted by phenoxy, phenyl substituted by heterocyclyl, phenyl substituted by heterocyclyl wherein said heterocyclyl is substituted by phenyl, phenyl substituted by -O-C1-4 alkyl -heterocyclyl, phenyl substituted by benzyloxy, phenyl substituted by carbocyclyl, phenyl substituted by carbocyclyl wherein said carbocyclyl is substituted by heterocyclyl, phenyl substituted by -O-carbocyclyl, heterocyclyl substituted by phenyl, carbocyclyl substituted by phenyl, phenyl fused to carboxy fused to heterocyclyl, C1-4 alkyl (phenyl substituted by phenyl), C1-4 alkyl (phenyl substituted by a monocyclic heteroaryl group), C1-4 alkyl (phenyl substituted by a monocyclic heterocyclyl group), alkyl C1-4- (phenyl substituted by a group -Ocarbocyclyl), C1-4 alkyl- (phenyl substituted by benzyloxy), C1-4 alkyl- (optionally substituted phenyl fused to optionally substituted carbocyclyl or C1-4 alkyl (optionally substituted phenyl fused to optionally substituted heterocyclyl); wherein any of the above-mentioned phenyl, benzyloxy and heteroaryl groups may be optionally substituted by one or more groups selected from C1-4 alkyl, halogen and C1-4 alkoxy; and wherein any of those of the aforementioned carbocyclyl or heterocyclyl groups may be optionally substituted by one or more groups selected from methyl, phenyl, oxo, halogen, hydroxyl and C1-4 alkoxy; R3 represents H, C1-4 alkyl or aryl; wherein the aforementioned aryl may be optionally substituted by one or more groups selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 thioalkyl, -SO C1-4 alkyl, -SO2-C1-4 alkyl, C1-6 alkoxy, -O3-8 cycloalkyl, C3-8 cycloalkyl, -SO2-cycloalkyl |