| abstract |
Compound of formula (I) including any stereochemically isomeric form thereof, wherein n is an integer 0, 1 or 2; X is SO, SO2 or N- (CO) -R1; R1 is hydrogen; C1-6alkyl; C1-6 alkyloxy; C1-4alkyloxy-C1-4alkyl; or polyhalo-C1-6alkyl; R2 is C1-6 alkyl; R3 is hydrogen, halo, C1-4alkyl, C1-4alkyloxy, trifluoromethyl or cyano; R4 is C1-8 alkyl; C1-8alkyl substituted with C3-8cycloalkyl; polyhalo-C1-8-alkyl; C1-8alkyl substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C1-4alkyloxy, polyhalo-C1-4alkyloxy, cyano, nitro, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, aryl or heteroaryl; C3-8 cycloalkyl; C3-8cycloalkyl substituted with 1, 2 or 3 substituents, each independently selected from hydroxy, C1-4alkyloxy, polyhalo-C1-4alkyloxy, cyano, nitro, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, aryl or heteroaryl; tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, aryl; or heteroaryl; aryl is phenyl; or phenyl substituted with 1, 2, or 3 selected substituents, each independently, of halo, hydroxy, C1-4alkyl, polyhalo-C1-4alkyl, C1-4alkyloxy, polyhalo-C1-4alkyloxy, cyano, nitro, NR5R6 , R7-carbonyl, R7-SO2-, or hydroxy substituted C1-4alkyl, NR5R6, R7-carbonyl or R7-SO2-; Heteroaryl is selected from furanyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, or pyrazinyl; wherein R5 and R6 are independently selected from hydrogen, C1-4alkyl, polyhalo-C1-4alkyl, aminosulfonyl or C1-8alkyl-sulfonyl; or R7 carbonyl; wherein R5 and R6, taken together with the nitrogen atom bearing R5 and R6, can form a pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl ring; and wherein R7 is C1-4alkyl, hydroxy, amino, amino, mono- or di- (C1-4alkyl) amino, (hydroxy-C1-4alkyl) amino, (C1-4alkyloxy, -C1-4alkyl ) amino, di- (C1-4alkyl) amino-C1-4alkyl, pyrrolidinyl, piperidinyl, morpholinyl, or N-methyl-piperazinyl; or a pharmaceutically acceptable acid addition salt thereof, or a solvate thereof. |