http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2548393-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3120ae9cab5bb4831f0cc16288966367 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 |
| filingDate | 2007-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0a8c96d6099407decd1d9731c21c3aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_836761fca8b3bec1c6820230d6c73865 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4821342d612e35406478646ac0b71d56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8da3f83530c8836780950c3da1066a29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07aa4c8cdfd7fcfb91115a6110a092f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de09bf167d16a691f63d26a992d0261b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d724031ef02623f99ff0d0804598b8e |
| publicationDate | 2015-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2548393-T3 |
| titleOfInvention | Insulin derivative |
| abstract | An insulin derivative having the formula ** Formula ** where Ins is a parent insulin moiety and Q1-Q2- [CH2] n-X1- [CH2] n -Q3- [CH2] n -X2- [CH2 ] n, -Q4- [CH2] n -X3- [CH2] n -Q5- [CH2] n -Z is a substituent and wherein the Ins is attached to the substituent via an amide bond between the α- group amino of the amino acid residue that is located at the N-terminus of the B chain of Ins or an ε-amino group of a residue of Lys that is present on the A or B chain of Ins and a CO group in Q1 or Q2 of the substituent; each of the n is independently 0, 1, 2, 3, 4, 5 or 6; Q1 is: - an amino acid amide of an amino acid with a carboxylic acid in the side chain, or an amino acid with an uncharged side chain, the residue of which forms, with its carboxylic acid group, an amide group together with the α group -amino of the amino acid residue that is located at the N-terminus of the B chain of Ins or together with the ε-amino group of a residue of Lys that is present on the A or B chain of Ins, or - one chain consisting of two, three or four amino acid or amino acid α-amide residues as specified above, which are linked together through amide bonds, the chain of which - through an amide bond - is linked with the α-amino group of the amino acid residue that is located at the N-terminus of the B chain of Ins or with the ε-amino group of a Lys residue that is present on the A or B chain of Ins, with the proviso that if an amino a in Q1 forms a bond with the rest of the substituent, the amine must be attached to the rest of the substituent through a carbonyl group; Q2 is a bond; Q3, Q4, and Q5, independently of each other, can be - - (CH2) m where m is an integer within the range of 6 to 32; * - a divalent hydrocarbon chain comprising 1, 2 or 3 groups -CH> = CH- and a number of groups -CH2- groups that is sufficient to give a total number of carbon atoms in the chain that is located within the range from 4 to 32; - -CO - ((CR5R6) 1-6 -NH-CO) -; * - - (CO- (CR5R6) 1-6 -CO-NH) 1-4-, where the R5 independently may be H, -CH3, - (CH2) 1-6CH3 or -CONH2 and the R6 of independently they can be H, -CH3, - (CH2) 1-6CH3; - -CO- (CH2) 0-3-Ar- (CH2) 0-3- where Ar can be an arylene or heteroarylene, which can be substituted with one or two groups that are selected from the set consisting of - CH3, - (CH2) 1-6-CH3, -CONR1R2 or -SO2NR1R2, where the R1 and R2, independently of each other, can be H, -CH3 or - (CH2) 1-6-CH3; - (CH2CH2O) and-; (CH2CH2CH2O) and-; (CH2CH2CH2CH2O) and-; (CH2CH2OCH2CH2CH2CH2O) and- or (CH2CH2CH2OCH2CH2CH2CH2O) and-; - (CH2OCH2) y- where y is 1-20; - an arylene or heteroarylene, which may be substituted with one or two groups that are selected from the group consisting of -CH3, - (CH2) 1-6-CH3, -CONR1R2 or -SO2NR1R2, where R1 and R2, independently of each other, can be H, -CH3 or - (CH2) 1-6-CH3; - a chain of the formula - (CH2) s-Y1-Ar) v1 -Y2- (CH2) w-Y3- (Ar) v2-Y4- (CH2) t-Y5- (Ar) v3-Y6- (CH2 ) zen where Ar is defined as above, the Y1 - Y6, independently of each other, can be O, S, S> = O, SO2 or a bond; where s, w, t and z, independently of each other, are zero or an integer from 1 to 10 such that the sum of s, w, t and z is within the range of 4 to 30, and v1, v2, and v3, independently of each other, can be zero or 1 with the proviso that the Y1 - Y6 are not to be linked with each other and that the structure -O- (CH2) is not to be presented 1-O-; or - a link; with the proviso that at least one of the Q3 - Q5 does not have to be a link; X1, X2 and X3 are, independently of each other, - O; - -C> = O - a link; - NCOR1, where R1 can be H, -CH3 or - (CH2) 1-6-CH3; or wherein R is hydrogen, C1-3alkyl, C2-3alkenyl, or C2-3alkynyl; with the proviso that - X1, X2 and X3 cannot be attached to Z and - when X1, X2 and X3 are O, then X1, X2 and X3 are not to be directly attached to O in Q3, Q4, and Q5 and Z is: -COOH; -CO-Asp; -CO-Glu; -CO-Gly; -CO-Sar; -CH (COOH) 2; -N (CH2COOH) 2; -SO3H -OSO3H -OPO3H2 -PO3H2 or -tetrazol-5-yl or -O-W1, where W1 is an arylene or heteroarylene, which may be substituted with one or two groups that are selected from the group consisting of tetrazo -5-lilo, -COOH, -SO3H, - (CH2) 1-6-SO3H, - (CH2) 1-6-O-PO3H2, -CONR3R4 or -SO2NR3R4, where R3 and R4, independently some others may be H, - (CH2) 1-6-SO3H, or - (CH2) 1-6-O-PO3H2; with the proviso that when Z is -O-W1 then Q1 must be present and any complex with Zn2 + thereof. |
| priorityDate | 2006-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 140.