http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2547571-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c564991ae13d25b7772e76de8d0160e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2011-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e2f7876f062549a462e8d25223d8e99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7cb55054f2b2b328afb1d4102908e24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21f0e5c16efb379bd98501b7727ada7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ac3a535cdd1cab899cdc0f9016ef1ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20a048a639c44ceb5b8c98cf9586ae35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a300568ae9603a6dc045350f5295e689 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fa284b8de31711c2579a246c57842e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_268e9adddb3e26c9effa58ecb91d723f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a924de80273a0f55d148c083f6804ce7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68de2e6eb8753b346dc7ca38d0b6a204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e9e144b18a19121571c9e1506c9a432 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_578b2b8184b3e0b25358174527f90ecf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94f9694787faf4216c7fb5a4f011340c |
| publicationDate | 2015-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2547571-T3 |
| titleOfInvention | Tricyclic compounds and PBK inhibitors that contain them |
| abstract | A compound represented by the general formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1 is C1-C6 alkyl optionally substituted with hydroxyl or halogen, halogen, hydrogen, cyano, C3-C10 cycloalkyl , C2-C6 alkenyl, or C2-C6 alkynyl; wherein R2 is hydrogen, hydroxyl, halogen, C1-C6 alkoxy, or C6-C10 aryl optionally substituted with hydroxyl; wherein R3 is selected from the group consisting of: hydroxyl; hydrogen; C1-C6 alkyl optionally substituted with hydroxyl, halogen, or hydroxyethylamino; halogen; C1-C6 alkoxy optionally substituted with dimethylamino or morpholinyl; C1-C6-alkyl-phenyl, in which the aliphatic carbons are optionally substituted with -NR51R52; cyano; nitro; Not me; 3-8 membered heterocycloalkyl optionally substituted with amino; heteroaryl; -OSO2CH3; -OSO2CF3; -OCOR103, where R103 represents C1-C6 alkyl; -OCOOR104, wherein R104 represents C1-C6 alkyl; -OCONR101R102, wherein R101 and R102 each independently represent hydrogen or C1-C6 alkyl, or R101 and R102, taken together, form morpholinyl; and -CONH2. wherein R4 is selected from the group consisting of C6-C10 aryl, hydroxyl, halogen, amino, C1-C6 alkyl, C2-C6 alkenyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C1 alkoxy -C6, indanyl, heteroaryl, and 3-8 membered heterocycloalkyl, and R4 is optionally substituted with substituent A; wherein substituent A is independently selected from the group consisting of: C1-C6 alkyl optionally substituted with substituent B; halogen; hydroxyl; oxo (> = O); cyano; C3-C10 cycloalkyl optionally substituted with cyano or C1-C6 alkyl substituted with -NR31R32, wherein R31 and R32 each independently represent hydrogen or C1-C6 alkyl; -NR21R22, where R21 and R22 each independently represent hydrogen; C1-C6 alkyl optionally substituted with hydroxyl, amino, di (C1-C6 alkyl) amino, -SO2 (C1-C6 alkyl), 3-8 membered heterocycloalkyl, or cyano; or a 3- to 8-membered heterocycloalkyl optionally substituted with -COOR105, wherein R105 represents C1-C6 alkyl; C1-C6 alkoxy optionally substituted with halogen, 3-8 membered heterocycloalkyl optionally substituted with C1-C6 alkyl, or -NR33R34, where R33 and R34 each independently represent hydrogen, C1-C6 alkyl sulfonyl, or alkyl C1-C6 optionally substituted with C1-C6 alkyl sulfonyl or di (C1-C6 alkyl) amino; -SO2NR23R24, where R23 and R24 each independently represent hydrogen; C1-C6 alkyl optionally substituted with hydroxyl, C1-C6 alkoxy, halogen, C3-C10 cycloalkyl, heteroaryl, or -NR35R36, where R35 and R36 each independently represent hydrogen or C1-C6 alkyl; C3-C10 cycloalkyl optionally substituted with C1-C6 hydroxyalkyl; 3-8 membered heterocycloalkyl; or R23 and R24, taken together, form 3-8 membered heterocycloalkyl optionally substituted with amino or halogen; C1-C6-alkyl-sulfonyl optionally substituted with hydroxyl; -NHSO2 (C1-C6 alkyl), where the carbon atoms are optionally substituted with -NR37R38, where R37 and R38 each independently represent hydrogen or C1-C6 alkyl; 3-8 membered heterocycloalkyl optionally substituted with -NR39R40, wherein R39 and R40 each independently represent hydrogen, C1-C6 alkyl, or C1-C6 alkyl sulfonyl; C1-C6 alkyl optionally substituted with -NR41R42, wherein R41 and R42 each independently represent hydrogen or C1-C6 alkyl; hydroxyl; or C1-C6-alkyl-sulfonyl; aryl optionally substituted with C1-C6 alkyl optionally substituted with cyano or amino; heteroaryl; -COOR11, where R11 represents hydrogen or C1-C6 alkyl; and -COR12, where R12 represents C1-C6 alkyl; C3-C10 cycloalkyl; cyanomethyl; aminomethyl; -NR25R26, where R25 and R26 each independently represent hydrogen or C1-C6 alkyl optionally substituted by hydroxyl or -NR43R44, where R43 and R44 each independently represent hydrogen or C1-C6 alkyl; or 3-8 membered heterocycloalkyl optionally substituted with C1-C6 alkyl; wherein substituent B is independently selected from the group consisting of: -NR51R52, where R51 and R52 each independently represent hydrogen; C1-C6 alkyl optionally substituted with C1-C6 alkyl sulfonyl or 3- to 8-membered heterocycloalkyl optionally substituted with -COOR53, wherein R53 represents hydrogen or C1-C6 alkyl; 3-8 membered heterocycloalkyl; C1-C6-alkyl-sulfonyl; C3-C10 cycloalkyl; -COR55, wherein R55 represents C1-C6 alkyl; - COOR56, in which R56 represents C1-C6 alkyl; or -CONR57R58, wherein R57 and R58 each independently represent hydrogen or C1-C6 alkyl. |
| priorityDate | 2010-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1386.