| abstract |
A compound according to the structure: ** Formula ** wherein: R1 is optionally substituted C1-10 alkyl; R2 is H optionally substituted C1-10alkyl; R3 and R4 are each independently selected from optionally substituted C1-10 alkyl; X, Y and Z are each independently selected from H; optionally substituted C1-10 alkyl; optionally substituted C1-10 alkoxy; optionally substituted C2-10 alkenyl; optionally substituted C2-10 alkynyl; optionally substituted C6-C12 aryl; alkaryl; arylalkyl; aryloxy; optionally substituted heteroaryl; optionally substituted heterocycle; halo; hydroxyl; halogenated alkyl; an amino group of the formula NH2, NR12H or NR12R13; alkylamino; arylamino; acyl; CN; NO2; N3; CH2OH; CONH2; CONR12R13; CO2R12; CH2OR12; NHCOR12; NHCO2R12; C1-3alkylthio; sulfate; sulfonic acid; sulfonate ester; phosphonic acid; phosphate; phosphonate; mono-, di- or triphosphate ester; trityl or monomethoxytrityl; R12SO; R12SO2; CF3S; CF3SO2; trialkylsilyl; and diphenylmethylsilyl; or where X and Y, or Y and Z form a fused aryl ring together with the phenyl ring to which X, Y and Z are attached; and R12 and Ri3 are each independently selected from H or optionally substituted C1-10 alkyl; except that one or more of X, Y and Z is optionally substituted C6-C12 aryl; or its pharmaceutically acceptable ester, amide, salt, solvate, stereo or geometric isomer. |