| abstract |
A recombinant hemagglutinin (rHA), comprising: a) a hemagglutinin domain selected from the group consisting of the subtypes of hemagglutinin H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, and H16; and b) an oligomerization domain selected from the group consisting of a GCN4-pII peptide and a proline-rich domain (PRD) of corn g-zein, wherein amino acid residues are added to the C-terminus of the oligomerization domain such that the oligomerization domain does not end in an α helix; c) signal peptide d) a retention signal in the endoplasmic reticulum (ER), and where rHA is produced as a chimeric soluble homotimer. |