| abstract |
A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: ** Formula ** wherein U represents -CF3, -CHF2 or -CH2F; Q represents oxygen, sulfur, N-R4 or a covalent bond; Z represents an optionally substituted bicyclic heteroaryl moiety consisting of two condensed six-membered aromatic rings, the heteroaryl moiety Z containing at least one nitrogen atom and being linked to the rest of the molecule by a carbon atom; M represents aryl or heteroaryl, any of whose groups may be optionally substituted by one or more substituents; W represents C-R5 or N; R1, R2 and R3 independently represent hydrogen, halogen, cyano, nitro, C1-6 alkyl, trifluoromethyl, cycloalkyl (C3-7) -alkyl (C1-6), heterocycloalkyl (C3-7) -alkyl (C1-6), aryl (C1-6) alkyl, heteroaryl (C1-6) alkyl, hydroxy, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, (C1-6) alkyl-thio, (C1-6) alkyl-sulfinyl, (C1 -6) -sulfonyl, amino, (C1-6) alkyl-amino, dialkyl (C1-6) -amino, (C2-6) alkylcarbonylamino, (C2-6) alkoxycarbonylamino, (C1-6) alkyl -sulfonylamino, formyl, (C2-6) alkylcarbonyl, carboxy, (C2-6) alkoxy, aminocarbonyl, (C1-6) alkyl-aminocarbonyl, dialkyl (C1-6) -aminocarbonyl, aminosulfonyl, (C1-alkyl) -6) -aminosulfonyl or dialkyl (C1-6) -aminosulfonyl; R4 represents hydrogen or C1-6 alkyl; and R5 represents hydrogen, halogen, C1-6 alkyl or C1-6 alkoxy. |