http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2543842-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_681ff6871f0118f0ac26adb6337c6bec |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-655354 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 |
| filingDate | 2007-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f0ee13d155b324985aeae6e4f831f26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8719f5e1b6cccda9f20c5435dd65be10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2983a4214de8ec482696468651bf850 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85f77b2e22b3b93ab5a82d4aa3c9aec1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4da66d79fc42037f31a2eb0b7796af03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d151e2efeeded05230bf145607a8767 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a0542a20b2c082614de18d7efac8800 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18b4c79abf7562097d107e2593094b0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_679fa824fdccb92af0b0edab2e9f21c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34ded2eb9538c2234908e44fe6c9167e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36de68814fca63facb10ecd73d15dd25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48c31860a45956f9e1483bbf8c339a90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45528f762f8b8ddf498a216f2ada0d48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46566e616d609f9bc6003f3aa3b1c672 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c577b3bc0631dad6bd089138d008c5ff |
| publicationDate | 2015-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2543842-T3 |
| titleOfInvention | New beta-lactamase inhibitors |
| abstract | A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: W represents: ** Formula ** Ra represents: (CH2) nRaa or Raa; Raa represents: ** Formula ** J represents N or CR1; K represents O, S or NR1; Het represents a 5-6 membered nitrogen-containing heterocycle, substituted with 0 to 4 groups of R2; T represents hydrogen, halogen, OR1 or C1-6 alkyl; R1 independently represents hydrogen or C1-6 alkyl; M is a negative charge, H or a pharmaceutically acceptable metal or ammonium salt, and with the proviso that when W contains a residue with multiple positive charges, there is an adequate number of LΘ present to provide overall neutrality; R2 and R5 independently represent hydrogen, halogen, cyano, -OR1 or C1-6 alkyl; R3 and R4 independently represent cyano, C1-6 alkyl, -Xm-Ym-Z * m-R8, or -Xm-Ym-Z * m-Q +; R7 represent hydrogen, halogen, cyano, -OR1, C1-6 alkyl, -Xm-Ym-Z * m-R8 or -Xm-Ym-Z * m-Q +; with the proviso that at least one of R3, R4 and R7 is -Xm-Ym-Z * m-Q +; X and Y are independently O, NRx, (C> = O), SO2, (CH2) n, - (CH2) nNR1C (O) -, - (CH2) nS- or - (CH2) nN (Rx) 2- ; Z * is (CH2) n which may be substituted with one to four Rb, R6 represents C6-10 aryl or C5-10 heteroaryl, said aryl and heteroaryl being optionally substituted; R8 represents halo, N (Rc) 2, -C (O) R5, NRcC (NH) NH2, NRcC (NH) H, (CH2) n-heterocyclyl C5-10, said heterocyclyl being optionally substituted; Q is selected from the group consisting of: ** Formula ** in which Z represents N + or carbon; and A is O, CH2, S (O) 0-2, NRx, or N + (Rx) 2; + represents a positively charged ion; LΘ represents a pharmaceutically acceptable counterion that is present as needed to provide charge balance in the molecule; a and b are 1, 2 or 3; α represents O, S or NRs; β, δ, λ, μ and σ represent CRt, N or N⊕ Rs, with the proviso that not more than one of β, δ, λ, μ and σ is N⊕ Rs; each Rb independently represents halo; -CN; -NO2; phenyl; -NHSO2Rc; -ORc, -SRc; - N (Rc) 2; -N + (Rc) 3; - C (O) N (Rc) 2; -SO2N (Rc) 2; heteroaryl; heteroarylium; formamidinyl, -CO2Rc; -C (O) Rc; -OC (O) Rc; -NHC (O) Rc; - NHC (O) 2Rc; guanidinyl; carbamimidoyl or ureido, said phenyl and heteroaryl being optionally substituted; each Rc independently represents hydrogen, a straight or branched chain C1-6 alkyl group, a C3-C6 cycloalkyl group or C6-10 aryl, said aryl being optionally substituted with one to four halogen groups; -CN; -NO2; phenyl; -NHSO2Rj; -OR1, -SRj; -N (Rj) 2; -N + (Rj) 3; -C (O) N (Rj) 2; -SO2N (Rj) 2; heteroaryl; heteroarylium; formamidinyl, -CO2Rj; -C (O) Rj; -OC (O) Rj; -NHC (O) Rj; -NHC (O) 2Rj; guanidinyl; carbamimidoyl or ureido, said phenyl and heteroaryl being optionally substituted, where Rj is selected from the group consisting of hydrogen, a straight or branched chain C1-6 alkyl group, a C3-C6 cycloalkyl group or C6-10 aryl group. each Rs independently represents hydrogen; phenyl or C1-6 alkyl of straight or branched chain, unsubstituted or substituted with one to four Rb groups; each R1 independently represents hydrogen; halo; phenyl; -CN; -NO2; -NRuRv; -ORu; -SRu; -C (O) NRuRv; - COORc; -SORu; -SO2Ru; -SO2NRuRv; -NRuSO2Rv; -C (O) Ru; - NRuC (O) Rv; -OC (O) Ru; -OC (O) NRuRv; -NRuCO2Rv; - NRuC (O) NRvRw; -OCO2Rv; straight or branched chain C 1-6 alkyl, unsubstituted or substituted with one to four Rb groups; Ru and Rv represent hydrogen or straight or branched chain C 1-6 alkyl, unsubstituted or substituted with one to four Rb groups; each Rw independently represents hydrogen; straight or branched chain C 1-6 alkyl, unsubstituted or substituted with one to four Rb groups; C3-6 cycloalkyl optionally substituted with one to four Rb groups; phenyl optionally substituted with one to four Rb groups, or heteroaryl optionally substituted with one to four Rb groups; Rx represents hydrogen or a linear or branched C1-8 alkyl chain, optionally interrupted with one or two of O, S, SO, SO2, NRw, N + RcRw or -C (O) -, said alkyl chain being unsubstituted or substituted with one to four halo groups, CN, NO2, -N3, ORw, SRw, SORw, SO2Rw, NRcRw, N + (Rc) 2Rw, Q, -C (O) -Rw, C (O) NRcRw, SO2NRcRw , CO2Rw, OC (O) Rw, OC (O) NRcRw, NRcC (O) Rw, NRcC (NH) NH2, NRcC (NH) H, NRcC (O) NRcRw, phenyl, naphthyl, heteroaryl or heterocyclic, said group being phenyl, heteroaryl and heterocyclic optionally substituted with one to four Rb groups or with one to two straight or branched chain C1-3 alkyl groups, said alkyl groups being unsubstituted or substituted with one to four Rb groups; Ry and Rz represent hydrogen; phenyl; straight or branched chain C 1-6 alkyl, unsubstituted or substituted with one to four Rb groups, and optionally interrupted by O, S, NRw, N + RcRw or -C (O) -; m represents 0 to 1; n represents 0 to 6; in which it is understood that when a value is zero, there is a link; and wherein alkyl is defined as a straight or branched chain aliphatic group having 1 to 12 carbon atoms, optionally substituted with one, two or three substituents; and where cycloalkyl is defined as a saturated or partially unsaturated cyclic hydrocarbon group having 3 to 12 carbon atoms, where the cycloalkyl group is optionally substituted. |
| priorityDate | 2006-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 779.