http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2543714-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9880469dc8f12dad7c3ad95c6ab31fe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-06 |
| filingDate | 2006-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0847136711e553f3ea3a57ed36b8629b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_067adff4ae8a35f4b296544e4c091a91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b5009bd08bb32d5acba06b635f515f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fafaddf43a9fd31e95d955e6ff4f56c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f499adf20e3c066f8ea448f36a9bd37f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49ecc6bcdce2fc8e2127ae1e2017831f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_161977ebfc9cc053df06e0f6206dd1c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bdb7a35cd88e0b62ce8dc0a773f97fb |
| publicationDate | 2015-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2543714-T3 |
| titleOfInvention | Azaindazole compounds and methods of use |
| abstract | A compound having a formula selected from the group consisting of: ** Formula ** or a pharmaceutically acceptable salt, hydrate or N-oxide thereof, wherein the subscript m is an integer from 0 to 4; R1 is a substituent independently selected from the group consisting of C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C3-C6 cycloalkenyl, -CO2Ra, -S (O) 3Ra, -X1CO2Ra, -X1SO2Ra, -X1S ( O) 3Ra, -X1OR3, -CORa, - CONRaRb, -X1NRaRb, -X1NRaCORb, -X1CONRaRb, X1S (O) 2NRaRb, X1S (O) 2Ra, -ORa, -NRaRb, -NRaCORb, -CCNRa-O, ) 2Rb, -S (O) 2NRaRb, -S (O) 2Ra, -X1CORa, X1CONRaRb, and -X1NRaS (O) 2Rb, where X1 is C1-C4 alkylene and each Ra and Rb is independently selected from the group consisting in hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, and C3-C6 cycloalkyl, and C3-C6 cycloalkenyl, or optionally Ra and Rb when anchored to the same nitrogen atom combine to form a 3- to 7-membered ring that has 0 to 2 additional heteroatoms as ring members; and wherein the aliphatic portions of each of said R1 substituents are optionally substituted with one to three members selected from the group consisting of -OH, -ORm, -OC (O) NHRm, -OC (O) N (Rm) 2 , -SH, -SRm, -S (O) Rm, -S (O) 2Rm, -SO2NH2, -S (O) 2NHRm, -S (O) 2N (Rm) 2, -NHS (O) 2Rm, - NRmS (O) 2Rm, -C (O) NH2, -C (O) NHRm, -C (O) N (Rm) 2, -C (O) Rm, -NHC (O) Rm, -NRmC (O) Rm, -NHC (O) NH2, -NRmC (O) NH2, -NRmC (O) NHRm, -NHC (> = NH) NH2, -NHC (> = NRm) NH2, -NRmC (> = NRm) N ( Rm) 2, -NRmC (> = NRm) NH (Rm), -NHC (> = NRm) NH (Rm), -NHC (> = NRm) N (Rm) 2, -NHC (> = NH) N ( Rm) 2, -NHC (> = NH) NH (Rm), -C (> = NH) NH2, -C (> = NRm) NH2, -C (> = NRm) N (Rm) 2, -C ( > = NRm) NH (Rm), -NHC (O) NHRm, -NRmC (O) N (Rm) 2, -NHC (O) N (Rm) 2, -CO2H, -CO2Rm, -NHCO2Rm, -NRmCO2Rm, -CN, -NO2, -NH2, NHRm, -N (Rm) 2, -NRmS (O) NH2 and -NRmS (O) 2NHRm, wherein each Rm is independently an unsubstituted C1-C6 alkyl; R2a, R2c and R2d are each substituents independently selected from the group consisting of hydrogen, halogen, cyano, aryl, heteroaryl, -NO2, -CO2Rc, -CONRcRd, -C (O) Rc, -S (O) Re, - S (O) 2Re, -S (O) 3Rc, -Re, -C (NORc) Rd, -C (NRcV)> = NV, -N (V) C (Rc)> = NV, -X2C (NORc) Rd, -X2C (NRcV)> = NV, -X2N (V) C (Rc)> = NV, -X2NRcRd, -X2SRc, -X2CN, -X2NO2, -X2CO2Rc, -X2CONRcRd, -X2C (O) Rc, - X2OC (O) NRcRd, -X2NRdC (O) Rc, -X2NRdC (O) 2Re, -X2NRcC (O) NRcRd, -X2NH-C (NH2) -NH, -X2NReC (NH2)> = NH, -X2NHC (NH2 )> = NRe, -X2NH-C (NHRc)> = NH, - X2S (O) Re, -X2S (O) 2Re, -X2NRcS (O) 2Re, -X2S (O) 2NRcRd, -X2N3, -ORc, -SRc, -NRdC (O) Rc, - NRdC (O) 2Re, -X2S (O) 3Rc, -S (O) 2NRcRd, -X2ORc, -O-X2ORc, -X2NRcRd, -O-X2NRcRd, -NRd- X2CO2Rc, -NRc-C (O) NRcRd, -NH-C (NH2)> = NH, -NReC (NH2)> = NH, -NH-C (NH2)> = NRe, -NH-C (NHRe)> = NH, NReC (NHRe)> = NH, -NReC (NH2)> = NRe, -NH-C (NHRe)> = NRe, -NH-C (NReRe)> = NH, NRcS (O) 2Rc, -NRcC (S) NRcRd, -X2NRcC (S) NRcRd, -X2OC (O) Rc, -O-X2CONRcRd, -OC (O) Rc, -NRcRd, -NRd-X2ORc and NRd-X2NRcRd, where in each of R2a , R2c and R2d, X2 is alq C1-C4 uylene and each of Rc and Rd are independently selected from hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, and C3-C6 cycloalkyl, or optionally, Rc and Rd when anchored to the same atom of nitrogen can be combined with the nitrogen atom to form a ring of five or six members having 0 to 2 additional heteroatoms as ring members; and each of Re is independently selected from the group consisting of C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl and heteroaryl, and each of Rc, Rd and Re is optionally further substituted with one to three members selected from the group consisting of -OH, -ORn, -OC (O) NHRn, -OC (O) N (Rn) 2, -SH, -SRn , -S (O) Rn, -S (O) 2Rn, -SO2NH2, -S (O) 2NHRn, -S (O) 2N (Rn) 2, -NHS (O) 2Rn, -NRnS (O) 2Rn, -C (O) NH2, -C (O) NHRn, -C (O) N (Rn) 2, -C (O) Rn, -NHC (O) Rn, -NRnC (O) Rn, -NHC (O ) NH2, -NR.C (O) NH2, -NRnC (O) NHRn, NHC (O) NHRn, -NRnC (O) N (Rn) 2, -NHC (O) N (Rn) 2, -CO2H, -CO2Rn, -NHCO2Rn, -NRnCO2Rn, -CN, -NO2, -NH2, -NHRn, -N (Rn) 2, -NRnS (O) NH2 and -NRnS (O) 2NHRn, where each Rn is independently an alkyl C1-C6 unsubstituted; and wherein V is independently selected from the group consisting of -Re, -CN, -CO2Re and - NO2; each of the annular vertices a, b, c and d in formulas Ia and Ib is independently selected from N and C (R3a), and from one to two of said annular vertices are N; and R3a is independently selected from the group consisting of hydrogen, halogen, -ORf, -OC (O) Rf, NRfRg, -SRf, -Rh, -CN, -NO2, -CO2Rf, -CONRfRg, -C (O) Rf , -OC (O) NRfRg, -NReC (O) Rf, -NRgC (O) 2Rh, -NRf-C (O) NRfRg, -NH-C (NH2)> = NH, -NRhC (NH2)> = NH , -NH-C (NH2)> = NRh, -NH-C (NHRh)> = NH, -C (> = NRf) NRgRh, -S (O) 3Rf, -S (O) Rh, -S (O ) 2Rh, -S (O) 3Rh, -NRfS (O) 2Rh, -S (O) 2NRfRg, -NRfS (O) 2Rh, -NRfS (O) 2NRfRg, -N3, -C (C> = NORf) NRfRg , -X3SO3Rf, -X3C (> = NRf) NRgRh, -X3ORf, -X3OC (O) Rf, -X3NRfRg, -X3SRf, -X3CN, -X3NO2, - X3CO2Rf, -X3CONRfRg, -X3C (O) Rf, O (O) NRfRg, -X3NRgC (O) Rf, -X3NRgC (O) 2Rh, -X3NRf- C (O) NRfRg, -X3NH-C (NH2)> = NH, -X3NRhC (NH2)> = NH, -X3NH -C (NH2)> = NRh, -X3NH-C (NHRh)> = NH, -X3S (O) Rh, -X3S (O) 2Rh, -X3NRfS (O) 2Rh, -X3S (O) 2NRfRg, -Y , -X3Y, -X3N3, -C (O) NRfS (O) Rh, -P> = O (ORf) (ORg), -X3C (O) NRfS (O) 2Rh, -X3C (O) NRfS (O) Rh and -X3P> = O (ORf) (ORg), wherein Y is a five to ten membered aryl, heteroaryl or heterocycloalkyl ring, optionally substituted with one to three substituents selected from the group that consists of halogen, -ORf, -NRfRg, -Rh, -SRf, -CN, -NO2, -CO2Rf, -CONRfRg, -C (O) Rf, -NRgC (O) Rf, -S (O) Rh, - S (O) 2Rh, -NRfS (O) 2Rh, -S (O) 2NRfRg, -X3ORf, - X3NRfRg, -X3NRfS (O) 2Rh and -X3S (O) 2NRfRg, and where each X3 is independently selected from the group consisting of C1-C4 alkylene, C2-C4 alkenylene and C2-C4 alkenylene; Rf and Rg are each independently selected from hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, heteroaryl, C1-C4 arylalkyl , and C1-C4 aryloxyalkyl, or when anchored to the same nitrogen atom can be combined with the nitrogen atom to form a five or six membered ring having 0 to 2 additional heteroatoms as ring members; and each of Rh is independently selected from the group consisting of C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, C1-C4 arylalkyl, and C1- aryloxyalkyl alkyl C4, wherein the aliphatic portions of X3, Rf, Rg and Rh are optionally further substituted with one to three members selected from the group consisting of -OH, -ORo, -OC (O) NHRo, -OC (O) N ( Ro) 2, -SH, -SRo, -S (O) Ro, -S (O) 2Ro, -SO2NH2, -S (O) 2NHRo, -S (O) 2N (Ro) 2, -NHS (O) 2Ro, -NRoS (O) 2Ro, -C (O) NH2, -C (O) NHRo, -C (O) N (Ro) 2, -C (O) Ro, -NHC (O) Ro, -NRoC (O) Ro, -NHC (O) NH2, NRoC (O) NH2, -NRoC (O) NHRo, -NHC (O) NHRo, NRoC (O) N (Ro) 2, -NHC (O) N (Ro ) 2, -CO2H, -CO2Ro, -NHCO2Ro, -NRoCO2Ro, -CN, -NO2, -NH2, -NHRo, -N (Ro) 2, -NRoS (O) NH2 and -NRoS (O) 2NHRo, where Ro is unsubstituted C1-C6 alkyl. |
| priorityDate | 2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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