http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2543376-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c89255f499b93234c1c2c09da69a4c02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-12 |
| filingDate | 2008-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b02f96357014110b834ddf9a4bb0f76e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b50542554abb84bf9e2cde2f1e376b3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54618e751a720511b7eb8c3c2bb2f89d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_333b5c89dfbffa9ccb8e2d8970f1d8a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f69a22c6f84ca99e81c16faebc004c86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c0c40e8dee8305acf48d001d799dff1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_252d2f82467e03366ca851fc6f31dedd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46549d9e16744273eb1313c77f28ef08 |
| publicationDate | 2015-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2543376-T3 |
| titleOfInvention | The method of preparation of (3S, 4S) -3-hexyl-4 - ((R) -2-hydroxytridyl) -oxetan-2-one and the product of that method |
| abstract | A method of preparation for a compound represented by the formula (I), ** Formula ** comprising the steps: a) reducing a substance represented by the formula (II) to obtain a substance represented by the formula (III) using a reducing agent, ** Formula ** wherein, in the formula (II), R1 represents a hydroxyl protecting group, and R2 represents a linear or branched saturated alkyl group, ** Formula ** wherein R1 in the formula ( III) has the same meaning as in formula (II), then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV) using an oxidation reagent under basic conditions, ** Formula ** wherein R1 in formula (IV) has the same meaning as in formula (II), the reduction reagent is selected from the group consisting of dimethyl borane sulfide, dimethyl borane sulfide / borohydride. sodium, sodium borohydride / aluminum trichloride, sodium borohydride / iodine, sodium borohydride / trimethylchlorosilane and sodium borohydride; b) acylate n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, and then condense the obtained n-octanoyl chloride with 2-mercaptopyridine under basic conditions to form a substance represented by the formula (V), ** Formula ** Next, the substance represented by formula (V) is converted to a substance represented by formula (VI) under basic conditions: where R1 in formula (VI) has the same meaning as in formula (II ); c) reacting the substance obtained in step a) with the substance obtained in step b) under Lewis acid catalytic conditions to form a substance represented by the formula (VII), ** Formula ** wherein R1 in the formula (VII) has the same meaning as in formula (II), then reacting with an acid to obtain the compound represented by formula (I); where, the sequence of step a) and step b) is alterable. |
| priorityDate | 2008-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 225.