| abstract |
Process for the production of crosslinked collagen matrices comprising the steps: a) prepare an aqueous collagen suspension, b) adjust the pH value of the collagen suspension from stage a) to pH <4, c) if necessary add other structure formers, active ingredients and / or auxiliary substances, d) add an epoxifunctional crosslinking agent, the order of stages c) and d) being variable, e) freeze the collagen mixture that can be obtained from stage d), f) lyophilize the frozen mixture from step e) at a lyophilization temperature <100 ° C g) optionally adjust the lyophilized crosslinked collagen material which can thus be obtained at a moisture content of up to 25% by weight, with respect to to the final product and h) if necessary transfer the materials that can be obtained from step g) to the desired mold, sterilize and / or make. |