http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2541531-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fda45c540f11df3a7fe71d54a70562a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2012-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46726b1c0e469e7b3edc3890e5e1e5da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e520ac5f570244e0e49bf70656fa9db9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e981e654f858d5338c4c1d9216548872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81f766c13e234225bb10cec9bb4fe438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe622411c63d3bb6a1b2fae75150dcb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_136edf795e06da10af529124593542d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd376962026f7dbeccd45d1c84bd7298 |
| publicationDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2541531-T3 |
| titleOfInvention | New pyrazole and imidazole derivatives useful as orexin antagonists |
| abstract | A compound of formula (I) ** Formula ** in which R 1 represents 5 to 10 membered aryl or heteroaryl, in which the 5 to 10 membered aryl or heteroaryl is independently unsubstituted or mono-, di- or tri -replaced; wherein the substituents are independently selected from the group consisting of: - (C1-4) alkyl, (C1-10 4) alkoxy, halogen, cyano, fluoroalkyl (C1-3), fluoroalkoxy (C1-3); and - -NR4R5, wherein R4 and R5 are independently hydrogen or (C1-4) alkyl; or R4 and R5 together with the nitrogen atom to which they are attached to form a 5- to 7-membered saturated ring optionally containing an oxygen atom; and - 5 or 6 membered phenyl or heteroaryl, wherein the 5 or 6 membered phenyl or heteroaryl is independently unsubstituted or mono- or di-substituted; wherein the substituents are independently selected from the group consisting of (C1-4) alkyl, (C1-4) alkoxy, halogen, cyano, fluoroalkyl (C1-3), fluoroalkoxy (C1-3); wherein at most one substituent selected from -NR4R5 and 5 or 6 membered phenyl or heteroaryl is present; U represents CH and V represents N; or U represents N and V represents CH; (R2) n represents one or two optional substituents, wherein each R2 is independently (C1-3) alkyl; and Y represents O or S; and ring A represents 5-10 membered aryl or heteroaryl, wherein said 5-10 membered aryl or heteroaryl is independently optionally substituted with (R3) m; wherein - (R3) m represents one, two or three optional substituents, in which each R3 is independently selected from the group consisting of: - (C1-4) alkyl, (C1-4) alkoxy, halogen, cyano , fluoroalkyl (C1-3), fluoroalkoxy (C1-3); and - 5 or 6 membered phenyl or heteroaryl, wherein the 5 or 6 membered phenyl or heteroaryl is independently unsubstituted or mono- or di-substituted; wherein the substituents are independently selected from the group consisting of (C1-4) alkyl, (C1-4) alkoxy, halogen, cyano, fluoroalkyl (C1-3), fluoroalkoxy (C1-3); which is present at most a 5 or 6 membered phenyl or heteroaryl substituent; - or (R3) m represents two substituents that form a 5 or 6 membered non-aromatic ring fused to the A ring, wherein said 5 or 6 member ring optionally contains one or two oxygen atoms; L represents a group - (CH2) m-, in which m represents the whole number 2 or 3; wherein said group L is optionally substituted with R6; wherein R6, if present, represents (C1-3) alkyl; and X represents a direct link, O, S or NR7; wherein, in the case where X represents NR7, - R7 represents hydrogen or (C1-3) alkyl; or, additionally, - R7 and R6 may form a 5 to 7 membered saturated ring that includes the nitrogen to which R7 is attached; - R7 together with one of the substituents R3 can form a 5 to 7 membered non-aromatic ring that includes the nitrogen to which R7 is attached, whose ring is fused to ring A; in which R6 is absent; and the remaining of said R3 substituents, if present, are independently selected from the group consisting of (C1-4) alkyl, (C1-4) alkoxy, halogen, cyano, fluoroalkyl (C1-3) and fluoroalkoxy (C1- 3); or a salt thereof. |
| priorityDate | 2011-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1096.