http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2540996-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b755982699e3ea5199d569ee5f5344c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2011-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_061d2155151bcfabec49e142248e0ccb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a0dde521d216c4d903a1e96937fb7fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6002628cb2cfd04bda582217d6347b12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2c19919673ebb898eed56952129d00e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_001bcd8f8bb8640d6ea58716c64c1ca8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79f8f31710dd056cf8f4cf7a7aaf7038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4b605e2be0d48264fb98defc4954de8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed6248ecdd4242024b6c84d882668833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b95bd7afa9ab68a9e88eab9211fab53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d00e33104faeb2e002bf25f665cb56c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad076be51536dca5f33d2582bbc61359 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7931265298dc2a2ca04ca25fb84c6b7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d0e4437eb431f753b0490d3803114e6 |
| publicationDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2540996-T3 |
| titleOfInvention | Compounds of substituted N- (1H-indazol-4-yl) imidazo [1,2-a] pyridin-3-carboxamide as type III receptor tyrosine kinase inhibitors |
| abstract | A compound with the general formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is hetAr1 (CH2) m-, hetAr2CH2-, hetAr3CH2-, (C3-6 cycloalkyl) -CH2-, hetCyc1CH2-, Ar1 ( CH2) n- or (N-C1-3alkyl) pyridinonyl-CH2-; hetAr1 is a 6-membered heteroaryl that has 1-2 N ring atoms and is optionally substituted with one or more substituents independently selected from: (C1-6) alkyl, (C1-4) alkoxy, halogen, CF3 or (C3) cycloalkyl -6); m is 0, 1 or 2; hetAr2 is a 5-membered heteroaryl ring having 2-3 ring heteroatoms independently selected from N and S where at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from alkyl ( C1-6); hetAr3 is a 5,6-fused, bicyclic heteroaryl ring having two ring nitrogen atoms; hetCyc1 is a 6-membered saturated heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O and optionally substituted with -C (> = O) (C1-6 alkyl) or - C (> = O) O ( C1-6 alkyl); Ar1 is phenyl optionally substituted with one or more substituents independently selected from: halogen, (C1-6) alkyl, CN, CF3, OH, (C1-6) alkoxy, -C (> = O) OH, -C (> = O) O ((C1-6) alkyl, - C (> = O) NRaRb or benzyloxy; Ra and Rb are independently H or (C1-6) alkyl; n is 0, 1 or 2; R2 is H, F, Cl or CH3; R3 is H, F or Cl; R4 is H, CN, F, Cl, Br, -OMe, -OCF3, -CF3, -CH (OH) CH2OH or -C (> = O) NH2; R5 is selected from: H, halogen, CN, OH, hetAr4, hetAr5, hetCyc2, hetCyc3 (C1-4 alkyl) -, hetCyc4alkoxy (C1-4), hetCyc5alkoxy (C1-4), (C1-3 alkoxy) alkoxy (C1 -4), hydroxyalkoxy (C1-6), dihydroxyalkoxy (C2-6), alkoxy (C1-6), [hydroxyalkyl (C2-4)) amino] -alkyl (C1-4), [(C1-4 alkoxy) (C1-4 alkyl) amino] (C1-4) alkyl, [di (C1-4 alkyl) amino] (C1-4) alkyl, (C1-4 alkyl) C (> = O) -, (C1-) hydroxyalkyl 6), dihydroxyalkyl (C2-6), [di (C1-3 alkyl) amino] (C1-4) alkoxy, N- (C1-3 alkyl) pyridinone, hetAr6, hetCyc6C (> = O) -, (hetCyc7) -O-, hetCyc8alkoxy (C1-4), difluoroaminoalkoxy (C1-4), [(C1-4 alkoxy) carbonyl gone] difluoroalkoxy (C1-4), (C1-4 alkyl) C (> = O) NHalkyl (C2-4) thio-, (C1-4 alkyl) OC (> = O) - or RcRdNC (> = O) -. |
| priorityDate | 2010-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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