| abstract |
A compound of the formula (I) or a salt thereof: ** Formula ** [wherein R 1 represents -O-C 1 -C 6 alkyl, -C 1-6 alkyl-phenyl, or -C 1-6 alkyl-pyridyl (en where phenyl or pyridyl can be substituted with carboxy or -CO-O-C1-C6 alkyl, -CO-O-C1-C6 alkenyl, -CO-O-C1-C6 alkynyl, -CO-O-C1-C6 alkylene- O-C1-C6 alkyl, -CO-O-C1-C6-aryl alkylene, -CO-O-C1-C6-O-aryl alkylene, -CO-NH2, -CO-NH-C1-C6 alkyl, -CO -N (C1-6 alkyl) 2, -CO-N (C1-C6 alkyl) aryl, -CO-N (C1-C6 alkyl) - (C1-C6 alkylene-aryl), -CO-NH-C1-alkylene C6-OH, -CO-NH-C1-C6-CO2H alkylene, -CO-O-methyl, -CO-O-ethyl, or -COO-tert-butyl), R2 and R3 are the same or different from each other and represent -H, C1-C6 alkyl, cycloalkyl, aryl, heteroaryl, saturated nitrogen containing hetero-ring, -C1-C6-aryl alkylene, or -C1-C6-heteroaryl (where C1-C6 alkyl, cycloalkyl, aryl, heteroaryl and saturated nitrogen-containing heterocycle may be substituted with halogen, -C1-C6 alkyl, pyridyl, ca rboxi, -CO-O-C1-C6 alkyl, -CO-O-C1-C6 alkenyl, -CO-O-C1-C6 alkynyl, -CO-O-C1-C6-O-C1-C6 alkyl, - CO-O-C1-C6-aryl-aryl, -CO-O-C1-C6-O-aryl, -CO-NH2, -CO-NH-C1-C6 alkyl, -CO-N (C1-C6 alkyl) 2, -CO-N (C1-C6 alkyl) aryl, -CO-N (C1-C6 alkyl) - (C1-C6 alkyl-aryl), -CO-NH-C1-C6-OH alkylene, -CO-NH -C1-C6-CO2H, -CO-O-methyl, -CO-O-ethyl, -COO-tert-butyl, amino which may be substituted with a -C1-C6 alkyl group, or the same or different two or plus -C1-C6 alkyl, -O-C1-C6 alkyl, - [CH (-OH)] mH, or -OH), or R2 and R3 can be combined with a nitrogen atom to which they are attached to form an amino saturated cyclic of 5 to 7 members (wherein the saturated cyclic amino of 5 to 7 members which may be substituted with halogen, -OH, oxo (> = O), -O-C1-C6 alkyl, cyano, nitro, cycloalkyl, aryl, heteroanillo, - C1-C6 alkylene-aryl, C1-C6 alkylene-heteroanillo, -C1-C6 alkyl (which may be substituted with halogen, - OH, -O-C1-C alkyl 6, or cyano), carboxy, -CO-O-C1-C6 alkyl, -COO-C1-C6 alkenyl, -CO-O-C1-C6 alkynyl, -CO-O-C1-C6-alkyl-C1-alkyl -C6, -CO-O-C1-C6-aryl alkylene, -CO-O-C1-C6-O-aryl alkylene, -CO-NH2, - CO-NH-C1-C6 alkyl, -CO-N (alkyl C1-C6) 2, -CO-N (C1-C6 alkyl) aryl, -CO-N (C1-C6 alkyl) - (C1-C6 alkyl-aryl), -CO-NH-C1-C6-OH alkylene, -CO-NH-C1-C6-CO2H alkylene, -CO-O-methyl, -CO-O-ethyl, -COO-tert-butyl or -CO-C1-C6 alkyl), the R4 'are the same or different between yes and represent halogen, C1-C6 alkyl, -OH, -O-C1-C6 alkyl, -NO2, or a group represented by the formula (II): ** Formula ** |