| abstract |
A whole blood derived clot device (WBCD) for the treatment of a bone defect in an individual comprising: (1) whole blood, (2) an osteogenic protein, (3) calcium chloride provided exogenously and (4 ) optionally, a mixture of fibrin and thrombin provided exogenously, in which the calcium chloride provided exogenously is present in an amount that is effective to provide a homogeneous, cohesive clot gel, which can be used in syringe, which is Injectable and malleable. |