| abstract |
Compounds of the formula ** Formula ** in which B1 is CR7 or N; B2 is CR8 or N; R1 is selected from the group consisting of phenyl, said phenyl being unsubstituted or substituted with one, two or three groups selected from the group consisting of C1-7 alkyl, C1-7 cycloalkyl, halogen, hydroxy, C1-7 alkoxy , halogen-C1-7 alkyl, halogen-C1-7 alkoxy, cycloalkyloxy, cycloalkyl-C1-7 alkoxy, cyano, cyano-C1-7 alkoxy, carboxyl, carboxy-C1-7 alkyl, C1-7 alkoxycarbonyl, hydroxy-alkyl C1-7, hydroxy-C1-7 alkoxy, C1-7 alkoxy-C1-7 alkyl, carboxy-C1-7 alkoxy, C1-7 alkoxycarbonyl-C1-7 alkoxy, amino, C1-7 alkylamino, di-C1- alkylamino 7, phenyl-C 1-7 alkoxy, heterocyclyloxy and heterocyclyl-C 1-7 alkoxy, wherein the heterocyclyl is unsubstituted or substituted with C 1-7 alkoxycarbonyl, heteroaryl, said heteroaryl being unsubstituted or substituted with one, two or three groups selected from the group consisting of C1-7 alkyl, C1-7 cycloalkyl, halogen, hydroxy, C1-7 alkoxy, halogen-C1-7 alkyl, halogen-C1-7 alkoxy, cycloalkyloxy, ci chloalkyl-C1-7 alkoxy, heterocyclyloxy and heterocyclyl-C1-7 alkoxy, wherein the heterocyclyl is unsubstituted or substituted with C1-7 alkoxycarbonyl, 3,6-dihydro-2H-pyran-4-yl, and piperidinyl, being said piperidinyl substituted with one to four C1-7 alkyl groups; R2 is selected from the group consisting of hydrogen, C1-7 alkyl, halogen, halogen-C1-7 alkyl, halogen-C1-7 alkoxy, cyano, C1-7 alkoxy, amino, C1-7 alkylamino, C1-alkylamino -7, aminocarbonyl, C 1-7 alkylaminocarbonyl, di- C 1-7 alkylaminocarbonyl, hydroxyC 1-7 alkyl- (C 1-7 alkyl) amino, C 1-7 alkoxy-C 1-7 alkyl- (C 1-7 alkyl) amino, and heteroaryl; R2a is selected from the group consisting of hydrogen, methyl and halogen; R3 is selected from the group consisting of C1-7 alkyl, halogen-C1-7 alkyl, hydroxy-C1-7 alkyl, C1-7 alkoxy-C1-7 alkyl, C1-7 alkylcarbonyl-C1-7 alkyl, carboxy- C1-7 alkyl, C1-7 alkoxycarbonyl-C1-7 alkyl, cyano-C1-7 alkyl, aminocarbonyl-C1-7 alkyl, alkylaminocarbonyl C1-7-C1-7 alkyl, di-alkylaminocarbonyl C1-7-C1-7 alkyl -, C1-7 alkyl-sulfonyl-C1-7 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-7 alkyl, unsubstituted heterocyclyl or heterocyclyl substituted with one or two groups selected from halogen, oxo, hydroxy and C1 alkyl -7, heterocyclyl-C 1-7 alkyl, wherein the heterocyclyl is unsubstituted or substituted with one or two groups selected from halogen, oxo and C 1-7 alkyl, heteroaryl-C 1-7 alkyl, in which the heteroaryl is without replace or substituted with one or two groups selected from halogen, oxo and C 1-7 alkyl and phenyl-C 1-7 alkoxycarbonylamino-C 1-7 alkyl; R4 is selected from the group consisting of hydrogen, halogen, C1-7 alkyl and C1-7 alkoxy; R5 and R6 are independently selected from each other from the group consisting of hydrogen, C1-7 alkyl, C1-7 cycloalkyl, halogen, halogen-C1-7 alkyl, halogen-C1-7 alkoxy, hydroxy, hydroxy-C1-alkyl 7, C 1-7 alkoxy, cyano, carboxyl, C 1-7 alkoxycarbonyl, C 1-7 alkoxycarbonyl, C 1-7 alkyl, hydroxyC 1-7 alkoxy, C 1-7 alkoxy-C 1-7 alkoxy, C 1-7 alkylsulfanyl, hydroxy C 1-7 alkylsulfanyl, C 1-7 alkoxy-C 1-7 alkylsulfanyl, C 1-7 alkylsulfonyl, C 1-7 hydroxy-alkylsulfonyl, C 1-7 alkoxy-C 1-7 alkylsulfonyl, C 1-7 carboxy-alkylsulfanyl, carboxy-C 1-7 alkylsulfonyl , C 1-7 alkoxycarbonyl-C 1-7 alkylsulfanyl, C 1-7 alkoxycarbonyl C 1-7 alkylsulfonyl, C 1-7 alkoxycarbonylamino- C 1-7 alkylsulfanyl, C 1-7 carboxy-alkyl-alkylcarbonyl-C 1-7 alkylsulfanyl, 7-aminocarbonyl-C 1-7 alkylsulfonyl. |