http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2538262-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a914e34dbd74b8c19c596970c5552591 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1016 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0819 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06104 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 |
| filingDate | 2007-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edfbaa243aeeff3cc9b51228a1d53d2c |
| publicationDate | 2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2538262-T3 |
| titleOfInvention | Michael's systems as transglutaminase inhibitors |
| abstract | Peptide or peptidomimetic of the following General Formula (I), (II) or (III): ** Formula ** where MS is the olefin substituted with acceptor of the following structure: ** Formula ** E means the following group -CH2 -, -CF2-, -C2H4-, -CH2-CF2-, -CF2-CH2-, -CH> = CH-, -CH (OH) -CH2-, -C (> = O) -CH2-, - CH2-NH-, -CH2-O-, -CH (OH) -CH2-NH-, -P (> = O) (OH) -NH-, -P (> = O) (OH) -O- , -P (> = O) (OH) -S-, -P (> = O) (OH) -CH2-, - CH (OH) -CH2-NH-, -C (> = O) -NH- , -C (> = O) -O- or -C (> = O) -NX "-; referring to ma 0 or 1; referring to residues Z1, Z2, Z3, independently of each other, to the following groups: -H , -CO- (C1-C6 alkyl), -COR 6, -COR7, -CO- (halo-C1-C6 alkyl), -CO- (C3-C10 heteroaryl), -CO- (C6-C15 aryl), -COO - (C1-C6 haloalkyl), -COO- (C3-C10 heteroaryl), -COO- (C6-C15 aryl), -COO- (C1-C6 alkyl), -COO-R8, -COO-R9, -CN , -COOH, -CONH (C1-C6 alkyl), -CO-N (C1-C6 alkyl) (C1-C6 alkyl), -CO-NR10R11, -CO-NH2, -NO2, -CON (CR12R13R14) (CR15R16R17 ), -CS- (C1-C6 alkyl), -CS-R18, -CS-R19, -CS-O- (C1-C6 alkyl), -CS-O-R20, -CSN (a C1-C6 alkyl) (C1-C6 alkyl), -CS-O-R21, -CSNR 22R23, -CS-NH2, -CS-N (CR24R25R26) (CR27R28R29), -SO-R30, -SO-R31, - SO2-R32, -SO2-R33, -SO-CR34R35R36, -SOCR 37R38R39, -SO2-CR40R41R42, -SO2-CR43R44R45, - SON (C1-C6 alkyl) (C1-C6 alkyl), -SO-NR46R47, -SO -NH2, -SON (CR48R49R50) (CR51R52R53), -SO2-N (C1-C6 alkyl) (C1-C6 alkyl), -SO2-NR54R55, -SO2-NH2, -SO2- N (CR56R57R58) (CR59R60R61), -SO2-OH, -SO2-OR62, -SO2-CR63R64R65, -SO2-OCR66R67R68, at least one of the residues Z1, Z2, Z3 being other than hydrogen; the residues Z1 and Z2 can also mean together a residue -CO-O-CO-CH2-, -CO-O-CH2-CH2-, and the residues Z2 and Z3 together can also mean a residue -CO-Z'-CH2- , -CO-O-CH2-, -CO-CH2-CH2-, - CO-O-CO- or -CO-NH-CO-, where Z 'refers to one of the following groups: -CH2-, - CF2-, -C2H4-, -CF2-CH2-, -CH2-CH2-, -O-, -O-CH2-, -NH- or -NHCH2-; Q and Q 'independently represent each other, a side chain residue of a natural amino acid or Q together with X' form a propylenyl moiety or Q 'together with X' 'form a propylenyl moiety; Y means a hydroxy group, amino group, C1-C6-alkyl group, dialkyl-C1-C6-amino group, C1-C6 alkoxy group, C6-C19 aryloxy group, C1-C6 alkyl group, C1-C6 haloalkyl group , C3-C10 heteroaryl group or a C6-C15 or Y aryl group refers to a peptide moiety linked through an amide bond of up to 6 amino acids, whose C-terminal carbonyl function carries a hydroxy group, amino group, C1-alkyl group -C6-amino, dialkyl-C1-C6-amino group, C1-C6 alkoxy group, C1-C6 alkyl group, C1-C6 haloalkyl group, C3-C10 heteroaryl group or a C6-C15 or Y aryl group refers to a peptidomimetic moiety of up to 60 carbon atoms, and X '' refers to hydrogen or a C1-C6 alkyl group; and -NXX 'means an amino group, -NH-CHO, alkyl-C1-C10-amino group, alkoxy-C1-C8-carbonylamino group, aralkyloxy-C6-C12-carbonylamino group, dialkyl-C1-C10-amino group, C2-C6 nitrogen heterocycle or a C3-C5 nitrogen heteroaryl group or the group -NXX 'is part of a peptidomimetic moiety of up to 60 carbon atoms, or X' refers to hydrogen or a C1-C6 alkyl group; Y |
| priorityDate | 2006-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 437.