http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2538215-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_307fbb9207b0aa3c48b7a715c25d2236 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2007-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fe48a1320316b11029f6fb62618b375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cd7d5cdb7ca825845e12c0527f0c9c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f80bd69d03a3876a4a3bf1b13f2f52c4 |
| publicationDate | 2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2538215-T3 |
| titleOfInvention | Kinase inhibitors useful for the treatment of myeloproliferative diseases and other proliferative diseases |
| abstract | Compound of formula I-1h: ** Formula ** in which: A is pyrazolyl, wherein ring A is optionally substituted with one or more R2 moieties; A1 is selected from the group consisting of those in which the symbol (**) is the point of attachment to ring A of formula I-1h; G1 is a heteroaryl taken from the group consisting of pyrrolyl, furyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyrazinyl, pyridazinyl, triazinyl, pyridinyl; G4 is a heterocyclyl taken from the group consisting of oxetanyl, azetadinyl, tetrahydrofuranyl, pyrrolidinyl, oxazolinyl, oxazolidinyl, imidazolonyl, pyranyl, thiopyranyl, tetrahydropyranyl, dioxalinyl, piperidinyl, morpholinyl, thiomorphyl oxide, thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorpholyl thiomorphyl oxideide , piperazinyl, azepinyl, oxepinyl, diazepinyl, tropanyl and homotropanyl; V, V1, and V2 are each independently selected and respectively from the group consisting of O and H2: each Z2 is independently and individually selected from the group consisting of hydrogen, aryl, C1-C6 alkyl, C3-C8 carbocyclyl, hydroxyl, hydroxyalkyl C1-C6-, cyano, (R3) 2N-, (R4) 2N-, (R4) 2Nalkyl C1-C6-, (R4) 2Nalkyl C2-C6N (R4) - (CH2) N-, (R4 ) 2 C2-C6O (CH2) n-, (R3) 2NC (O) -, (R4) 2NC (O) -, (R4) 2NC (O) C1-C6- alkyl, carboxyl, carboxyalkyl C1-C6-, C1-C6 alkoxycarbonyl-, C1-C6 alkoxycarbonylalkyl C1-C6-, (R3) 2NSO2-, (R4) 2NSO2-, -SO2R5, - SO2R8, - (CH2) nN (R4) C (O) R8, -C ( O) R8,> = O,> = NOH,> = N (OR6), - (CH2) nG1, - (CH2) nG4, - (CH2) nO (CH2) nG1, - (CH2) nO (CH2) nG4 , - (CH2) nNR3 (CH2) n-aryl, - (CH2) nNR3 (CH2) nG1, - (CH2) nNR3 (CH2) nG4, - (CH2) nNHC (O) NHS (O) 2R8, - (CH2 ) nNHS (O) 2NHC (O) R8, -C (O) NHS (O) 2R8, - (CH2) nNHC (O) (CH2) nR5, - (CH2) nNHS (O) 2R5, - (CH2) nC (O) NH (CH2) qR5, - (CH2) nC (O) R5, - (CH2) nOC (O) R5 and - (CH2) nR5; in the case where Z2 contains an alkyl or alkylene moiety, such moieties may be further substituted with one or more C1-C6 alkyls; each Z3 is independently and individually selected from the group consisting of H, C1-C6 alkyl, branched C3-C7 alkyl, C3-C8 carbocyclyl, halogen, C1-C6 fluoroalkyl wherein the alkyl moiety may be partially or fully fluorinated, cyano , hydroxy, methoxy, oxo, (R3) 2NC (O) -, (R4) 2NC (O) -, -N (R4) C (O) R8, (R3) 2NSO2-, (R4) 2NSO2-, -N (R4) SO2R5, -N (R4) SO2R8, - (CH2) nN (R3) 2, - (CH2) nN (R4) 2, -O (CH2) qN (R4) 2, -O (CH2) qO- C1-C6 alkyl, -N (R3) (CH2) qO-C1-C6 alkyl, -N (R3) (CH2) qN (R4) 2, -O (CH2) qR5, -NR3 (C2) qR5, -C (O) R5, -C (O) R8, -R5 and nitro; in the case where Z3 contains an alkyl moiety or an alkylene, such moieties may also be substituted with one or more C1-C6 alkyls; each Z4 is independently and individually selected from the group consisting of H, C1-C6 alkyl, C2-C6 hydroxyalkyl, C1-C6 alkoxyC2-C6- alkyl, (R4) 2N-C2-C6 alkyl-, (R4) 2N- C2-C6N alkyl (R4) -C2-C6 alkyl-, (R4) 2N-C2-C6-O-alkyl C2-C6-, (R4) 2NC (O) -C1-C6 alkyl-, C1-C6 carboxyalkyl -, C1-C6 alkoxycarbonyl C1- C6-, -C2-C6N (R4) C (O) R8, R8-C (> = NR3) -, - SO2R8, -COR8, - (CH2) nG1, - (CH2 ) nG4, - (CH2) qO (CH2) nG1, - (CH2) qO (CH2) nG4, - (CH2) qNR3 (CH2) nG1, - (CH2) qNR3 (CH2) nG4, - (CH2) qNHC (O ) (CH2) n5, - (CH2) qC (O) NH (CH2) qR5, - (CH2) qC (O) R5, - (CH2) qOC (O) R5, - (CH2) qR5, - (CH2) qNR4 (CH2) qR5, and - (CH2) qO (CH2) qR5. |
| priorityDate | 2006-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 62.