http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2537424-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_331acb2d2e4707f43b8f6c3cf6f79ab2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 |
| filingDate | 2009-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3455a6670adb03f8315f87492207c2d6 |
| publicationDate | 2015-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2537424-T3 |
| titleOfInvention | Derived from avermectin and milbemycin dimers |
| abstract | Compound of formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** in which: A is a single or double bond; B is a single or double bond; R1 and R5 are independently hydrogen, hydroxyl, oxo, oximino or alkoxyimino, provided that R1 is hydroxyl only when A is a single bond, and that R5 is hydroxyl only when B is a single bond; R2 and R6 are independently straight or branched C1-C8 alkyl, C2-C8 alkenyl, or C3-C8 cycloalkyl; R3 and R7 are independently hydroxyl, methoxy, oxo, hydroxyimino, or alkoxyimino; R4 and R8 are independently hydrogen, hydroxy, C1-C8 alkanoyloxy, benzoyloxy, di-C1-C8alkyl amino benzoyloxy, (C1-C8 alkoxy) p, C1-C8alkylthio, C1-C8alkylthioalkoxy or oleandrosiloxy; R9 and R10 are independently dirradic groups selected from one bond, O, NR11, -NR11C (> = O) -, - NR11C (> = S) -, -NR11C (> = O) O-, -ONR11C (> = O ) -, -ONR11C (> = O) O-, -ONR11C (> = O) NR11-, -OC (> = O) O-, -N (R11) C (> = O) N (R11) -, - N (R11) C (> = S) N (R11) -, -N (R11) S (O) 2N (R11) -, -N (R11) S (O) 2-, -N (R11) S (O) N (R11) -, -N (R11) S (O) -, -C (> = NR11) -, -C (> = O) -, - C (> = O) N (R11) - , and -C (> = S) N (R11) -; R11 is H or R2; L is a dirradical linker selected from a bond, C1-C20 alkylene, C2-C20 alkenylene, C2-C20 alkynylene, C3-C8 cycloalkylene, arylene, aryloxy arylene, heteroarylene, or any combination thereof, which may optionally contain an atom of N, O, S, P, or Si; and wherein said linker may be optionally substituted with one or more groups selected from cyano, nitro, hydroxy, halogen, O, N, S, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 thioalkyl , oxo, oximino, and alkoxyimino; m and n are independently 0, 1, or 2; and p is 1-3; where R9 and R10 may be connected to either of two atoms of the L-linker. |
| priorityDate | 2008-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 996.