http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2536980-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb382c3cb867647efff8c313c330bf0b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec53c86d72ae465e32b25f52665bddec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3ed32ad65a2035640a62a2f19925dcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc968aea936849077ae3cc25acd1628b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dffe657c0540ce845a5e5f82223a5e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3015472bedace50eb4891982615bd47e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ac69fe1f5b55a37afcf2edf72d4d206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b71d5bb4bdd2313c6e7fa22d4f909ac1 |
| publicationDate | 2015-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2536980-T3 |
| titleOfInvention | Aryl triazole compounds with antitumor activity |
| abstract | A compound of general formula I ** Formula ** in which, R1 is H, CONR4R5; R5 is H, (C1-C6) -alkyl or (C3-C10) -cycloalkyl each of which is optionally substituted one or more times with OH, OMe, Cl, F; R4 is H, (C1-C4) -alkyl or CH (R11) COR12; or R4 and R5 together with the nitrogen atom to which they are attached form a three to seven membered heterocycle optionally containing another heteroatom chosen from the group consisting of N, O or S; and wherein said heterocycle is optionally substituted one or more times with OH, OMe, (C1-C4) -alkyl, optionally substituted phenyl, or benzyl; R11 is a side chain of a natural α-amino acid; R12 is OH, amino, alkylamino or dialkylamino; R2 is a bond, -NH (CO) -, -N (R7) - or -N (R7) CH2-; R7 is H, (C1-C4) -alkyl or CO2R8; R8 is (C1-C4) -alkyl or benzyl; Endocyclic symbols --- are, for each compound, all double bonds or all simple bonds; m is an integer between 0 and 3; R9 and R10 are independently of each other (C1-C4) -alkyl optionally substituted with OH, cycloalkyl, heterocycloalkyl, OMe, amino, (C1-C6) -alkylamino or (C1-C6) -dialkylamino; heterocycloalkyl optionally substituted one or more times with alkyl, amino, (C1-C6) -alkylamino or (C1-C6) -dialkylamino; cycloalkyl; or R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from the group consisting of piperidyl, pyrrolidinyl, piperazinyl or morpholinyl, each of which is optionally substituted one or more times with F, Cl, Br , OH, OMe, amino, (C1-C6) -alkylamino, (C1-C6) -dialkylamino, (C1-C4) -alkyl, hydroxyalkyl, optionally substituted phenyl or benzyl; or an unsaturated imidazole heterocycle; R3 is Cl, Et or i-Pr; their tautomers, their geometric isomers, their optically active forms such as their enantiomers, diastereoisomers and racemates, as well as their pharmaceutically acceptable salts. |
| priorityDate | 2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 317.