http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2536762-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96b882006e755dfc56fcabfc5fb019f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 |
| filingDate | 2007-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e707061710b5208bfc3b02ceed46ca6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc1d0cf1ee666620cd636c67b04f8530 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc83468f61705c461a292c3edbd6ec9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_859c05a117645a37f9e72e5fc5f8fdde http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee2f70966efdc66e94d9714d0c5a982c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5585ee367b44e724444b5872094ebd05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97c52bc7859a8b5d48083fef9cc6f872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_050aef411713effdf0eee28b53b6df80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_056b7f07382648dc4f0def62cd1a676f |
| publicationDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2536762-T3 |
| titleOfInvention | Primary amines and their derivatives as 5-HT2A serotonin receptor modulators useful for the treatment of disorders related to this |
| abstract | A compound selected from compounds of Formula (Ia) and pharmaceutically acceptable salts, hydrates, and solvates thereof: ** Formula ** in which: X is O or S; V is O or NH; W is C1-4 alkylene optionally substituted with 1,2, 3, 4, 5, 6, 7 or 8 substituents independently selected from C1-3 alkyl, C1-4 alkoxy, carboxy, cyano, C3-7 cycloalkyl, C1- haloalkyl 3, halogen, oxo and imino, wherein said C1-3 alkyl is optionally substituted with C1-3 alkylsulfonyl; Z is C1-4 alkylene optionally substituted with 1,2, 3, 4, 5, 6, 7 or 8 substituents independently selected from C1-3 alkyl, C1-4 alkoxy, carboxy, cyano, C1-3 haloalkyl, halogen and oxo ; or Z is absent; R1 is selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-7 cycloalkyl; R2 is selected from H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkylcarboxamide, C2-6 alkynyl, C1-6 alkylsulfonamide, C1-6 alkylsulfinyl , C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 alkylureyl, amino, C1-6 alkylamino, C2-8 dialkylamino, C1-6 carbo alkoxy, carboxamide, carboxy, cyano, C3-7 cycloalkyl, C2-8 dialkylcarboxamide , C2-8 dialkylsulfonamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl, C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, hydroxyl, thiol, nitro and sulfonamide; R 3 is selected from H, C 2-6 alkenyl, C 1-6 alkyl, C 1-6 alkylcarboxamide, C 2-6 alkynyl, C 1-6 alkylsulfonamide, C 1-6 carboxy alkoxy, carboxamide, carboxy, cyano, C 3-7 cycloalkyl, dialkylcarboxamide C2-8, halogen, heteroaryl and phenyl; and wherein each of the C2-6 alkenyl, C 1-6 alkyl, C 2-6 alkynyl, C 1-6 alkylsulfonamide, C 3-7 cycloalkyl, heteroaryl and phenyl groups is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-5 acyl, C1-5 acyloxy, C2-6 alkenyl, C1-4 alkoxy, C1-8 alkyl, C1-6 alkylamino, C2-8 dialkylamino, C1-4 alkylcarboxamide, C2-6 alkynyl, C 1-4 alkylsulfonamide, C 1-4 alkylsulfinyl, C 1-4 alkylsulfonyl, C 1-4 alkylthio, C 1-4 alkylureyl, amino, C 1-6 carboxy alkoxy, carboxamide, carboxy, cyano, C 3-6 cycloalkyl, C 2-6 dialkylcarboxamide, halogen, C1-4 haloalkoxy, C1-4 haloalkyl, C1-4 haloalkylsulfinyl, C1-4 haloalkylsulfonyl, C1-4 haloalkylthio, hydroxyl, nitro and sulfonamide; R4a is H; R4b is H, C1-12 acyl, C1-6 carbo-alkoxy, or C (> = O) O-aryl, wherein said C1-12 acyl, C1-6 carbo-alkoxy, and -C (> = O ) O-aryl are each optionally substituted with 1, 2, 3, 4, or substituents independently selected from C 1-6 alkylcarboxamide, amino, C 1-6 alkylamino, C 2-8 dialkylamino, C 1-6 alkylimino, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 alkylthio, halogen, nitro, and phenyl; or R4b is -C (> = O) OCRaRbOC (> = O) Rc, in which Ra, Rb and Rc are each independently selected from H, or C1-6 alkyl; R5, R6 and R7 are each independently selected from H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkylcarboxamide, C2-6 alkynyl, C1 alkylsulfonamide -6, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 alkylthio, C 1-6 alkylureyl, amino, C 1-6 alkylamino, C 2-8 dialkylamino, C 1-6 alkylamino, C 1-6 alkoxy, carboxyamide, carboxy , cyano, C3-7 cycloalkyl, C2-8 dialkylcarboxamide, C2-8 dialkylsulfonamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl, C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, heterocyclyl, hydroxyl , and nitro; and R 8 is C 1-8 alkyl, aryl, C 3-10 cycloalkyl, heteroaryl, or heterocyclyl, each optionally substituted with substituents independently selected from C 1-6 acyl, C 1-6 acyloxy, C 2-6 alkenyl, C 1-6 alkoxy, alkyl C1-6, C1-6 alkylcarboxamide, C2-6 alkynyl, C1-6 alkylsulfonamide, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 alkylureyl, amino, C1-6 alkylamino, C2-8 dialkylamino , C1-6 alkylimino, C1-6 carbo-alkoxy, carboxamide, carboxy, cyano, C3-7 cycloalkyl, C3-7 cycloalkyloxy, C2-8 dialkylcarboxamide, C2-8 dialkylsulfonamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl , C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, heteroaryl, heterocyclyl, hydroxyl, thiol, nitro, phenoxy and phenyl, wherein said C2-6 alkenyl, C1-6 alkyl, C2-6 alkynyl, alkylamino C1-6, C1-6 alkylimino, C2-8 dialkylamino, heteroaryl, heterocyclyl, phenyl, and phenoxy, and each of said substituents is optionally substituted do with 1, 2, 3, 4, or 5 substituents independently selected from C 1-6 acyl, C 1-6 acyloxy, C 2-6 alkenyl, C 1-6 alkoxy, C 1-6 alkyl, C 1-6 alkylcarboxamide, C 2-6 alkynyl , C1-6 alkylsulfonamide, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 alkylureyl, amino, C1-6 alkylamino, C2-8 dialkylamino, carbo- C1-6 alkoxy, carboxamide, carboxy, cyano , C3-7 cycloalkyl, C2-8 dialkylcarboxamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl, C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, heterocyclyl, hydroxyl, thiol and nitro. |
| priorityDate | 2006-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1438.