| abstract |
Reconstituted viral membrane for pharmaceutical use by intranasal administration, its lipid bilayer comprising a fusion protein of a virus, an amphiphilic adjuvant and, optionally, an additional antigen, in which: (a) the lipid bilayer has a lipid composition that it is compatible with the fusion, induced by the fusion protein, of the viral membrane with the membrane of a cell that can be fused with the virus from which the fusion protein has been derived, (b) the fusion protein and the amphiphilic adjuvant interact with the hydrophobic interior of the lipid bilayer; and (c) the fusion protein, the amphiphilic adjuvant and the optional additional antigen are not covalently bound, wherein the amphiphilic adjuvant is a lipopeptide that is a ligand for a mammalian Toll-like receptor. |