http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2536687-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2008-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e710223adc9824e9ad8d19fc8985e24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fba81a5582ad9cce287ce596442f685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689aab58e11274b992bd64a96a660086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33847004584372a0068499425f39b15e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcf3e9718f9f068f5af6edf6fc9bb9f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4acb07b47ee767806a0f90ef8b59c0b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_272d98168fe56302af9cffab157932dd |
| publicationDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2536687-T3 |
| titleOfInvention | Pyrimidine [2,3-d] pyrimidines substituted with 6-cyano as adenosine receptor ligands for the treatment of cardiovascular diseases |
| abstract | Compound of formula (I) ** Formula ** in which ring Q represents a group of formula ** Formula ** in which * means the C2 atom binding site, means the C3 atom binding site, R6 represents respectively hydrogen, (C1-C4) alkyl or allyl, and (C1-C4) alkyl may be substituted with a substituent selected from the group of hydroxycarbonyl, alkoxy- (C1-C4) -carbonyl and amino, X represents S or O, R1 represents (C6-C10) aryl or 5-10 membered heteroaryl, where (C6-C10) aryl and 5-10 membered heteroaryl can be substituted with 1 or 2 substituents selected independently from the group of halogen, nitro, cyano, alkyl (C1-C6), trifluoromethyl, hydroxyl, (C1-C6) alkoxy, amino, mono-C1- C6-alkyl-amino, di-C1-C6-alkyl-amino, hydroxycarbonyl, (C1-) alkoxy C6) -carbonyl, aminocarbonyl, mono-C1-C6-alkyl-aminocarbonyl, di-C1-C6-aminocarbonyl, pyrrolidino, piperidino, morpholino, piperazino and N'-C1-C4-alkyl- piperazi no, 5- or 6-membered phenyl and heteroaryl, and 5- and 6-membered phenyl and heteroaryl may be substituted with 1 to 3 substituents independently selected from the group of halogen, nitro, cyano, (C1-C6) alkyl, difluoromethyl, trifluoromethyl , hydroxyl, (C1-C6) alkoxy, difluoromethoxy, trifluoromethoxy, amino, mono-C1-C6-alkyl-amino, di-C1- C6-amino, hydroxycarbonyl and alkoxy- (C1-C6) - Carbonyl, R2 represents (C5-C6) cycloalkyl, 5- or 6-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl, wherein (C5-C6) cycloalkyl can be substituted with 1 or 2 substituents independently selected from the group of (C1-C6) -alkyl, hydroxyl, oxo, (C1-C6) -alkoxy, amino, mono-alkyl- (C1-C6) -amino and di-alkyl- (C1-C6) -amino, whereby (C1- C6) and (C1-C6) alkoxy substituted with 1 or 2 substituents independently selected from each other from the group of hydroxyl, (C1-C4) alkoxy and (C3-C7) cycloalkyl, and may be c icloalkyl (C3-C7), on the other hand, substituted with 1 or 2 substituents independently selected from the group of (C1-C4) -alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and in which 5 or 6-membered heterocyclyl can be substituted with 1 to 3 substituents independently selected from the group of oxo, thioxo, hydroxyl, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) -alkyl-carbonyl, amino, mono-alkyl- (C1-C6) -amino, di-(C1-C6) -alkyl-amino and (C3-C7) cycloalkyl, (C1-C6) alkyl may be substituted with 1 to 3 substituents independently selected from the group of fluorine, oxo, hydroxyl, trifluoromethyl, (C1-C4) alkoxy, alkyl- (C1-C4) -carbonyloxy, amino, monoalkyl- (C1-C4) -amino, di-(C1-C4) -amino and cycloalkyl (C3 -C7), whereby (C3-C7) cycloalkyl may be substituted by 1 or 2 substituents independently selected from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and may be alkyl - (C 1-C6) -carbonyl substituted with a substituent selected from the group of hydroxyl and (C1-C4) alkoxy, and may be (C3-C7) cycloalkyl substituted with 1 or 2 substituents independently selected from the group of (C1-C4) alkyl. ), hydroxyl, oxo and (C1-C4) alkoxy, and wherein 5- or 6-membered phenyl and heteroaryl may be substituted with 1 to 3 substituents independently selected from the group of halogen, cyano, hydroxyl, (C1-C6 alkyl). ), (C1-C6) alkoxy, (C3-C7) cycloalkoxy and -NRARB, where (C1-C6) alkyl may be substituted with 1 to 3 substituents selected from the group of fluorine, and where (C1-C6) alkoxy may be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, (C3-C7) cycloalkyl, oxo, hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl, amino, mono-(C1-C4) -alkyl-amino and di -C1-C4-alkyl-amino, and the (C3-C7) cycloalkoxy may be substituted with 1 or 2 selected substituents independently ionized from each other of the group of (C1-C4) -alkyl, hydroxyl, oxo and (C1-C4) -alkoxy, and where RA represents hydrogen or (C1-C6) -alkyl, whereby (C1-C6) -alkyl may be substituted with a substituent selected from the group of hydroxyl and (C1-C4) alkoxy, RB represents hydrogen, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C4) -alkyl-sulfonyl or cycloalkyl- (C3- C7) - sulfonyl, whereby (C1-C6) alkyl may itself be substituted by 1 or 2 substituents independently selected from the group of (C3-C7) cycloalkyl, oxo, hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl, amino , mono-(C1-C4) -alkyl-amino and di-(C1-C4) -alkyl-amino, and the cycloalkyl (C3-C7) may itself be substituted by 1 or 2 substituents independently selected from the group of (C1-C4) alkyl, hydroxyl, oxo, and (C1-C4) alkoxy, or two adjacent substituents may be formed on the phenyl together with the carbon atoms to which a 1,3-d is attached ioxolane or 2,2-difluoro-1,3-dioxolane, as well as their N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides. |
| priorityDate | 2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 918.