| abstract |
Compound according to formula 1: ** Formula ** in which the compound shows cytotoxic activity and: R2 is hydrogen or dimethylamino, R3 is hydrogen, R4 is cycloalkyl optionally substituted with alkyl, or benzyl optionally substituted with halogen, or R3 and R4 , together with the nitrogen atom to which they are attached, form piperidinyl substituted with one or more substituents selected independently from the group consisting of: hydroxyl and phenyl optionally substituted with halogen, R5 is alkyl or benzyl optionally substituted with halogen, and R6 is benzodioxolyl or phenyl optionally substituted with one to three substituents independently selected from the group consisting of: halogen, hydroxyl, alkoxy optionally substituted with halogen, alkyl, phenoxy optionally substituted with halogen, cyano or alkyl and phenyl optionally substituted with alkyl or halogen, or a pharmaceutically acceptable salt thereof. |