| abstract |
A modified siRNA molecule to silence the pole type kinase 1 expression (PLK-1), in which the modified siRNA molecule comprises a sense strand consisting of the nucleic acid sequence of SEQ ID No. 400, an antisense strand. complementary, and a double stranded region of at least 15 nucleotides in length, and in which the antisense strand comprises one or more modified nucleotides in the double stranded region selected from the group consisting of 2'OMe-guanosine nucleotides, 2 'nucleotides OMe-uridine, and mixtures thereof. |