http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2535172-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-54 |
filingDate | 2008-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e710223adc9824e9ad8d19fc8985e24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689aab58e11274b992bd64a96a660086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fba81a5582ad9cce287ce596442f685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33847004584372a0068499425f39b15e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcf3e9718f9f068f5af6edf6fc9bb9f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4acb07b47ee767806a0f90ef8b59c0b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_272d98168fe56302af9cffab157932dd |
publicationDate | 2015-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2535172-T3 |
titleOfInvention | 3,4-Dihydro-4-oxo-5-aryl-pyrido [2,3-d] pyrimidin-6-carbonitriles as adenosine receptor ligands for the treatment of cardiovascular diseases |
abstract | Compound of formula (I), ** Formula ** in which ring Q represents a group of formula ** Formula ** in which * means the C2 atom binding site, means the C3 atom binding site, R6 represents hydrogen or (C1-C4) alkyl or allyl, (C1-C4) alkyl may be substituted with a substituent selected from the group of hydroxycarbonyl, alkoxy- (C1-C4) -carbonyl and amino, R7 represents hydrogen, (C1-alkyl) -C4), trifluoromethyl, amino, mono-(C1-C4) -alkyl-amino or di-(C1-C4) -alkyl-amino, whereby (C1-C4) -alkyl may be substituted with 1 or 2 substituents independently selected from each other from the hydroxyl, methoxy and amino group, X represents S or O, R1 represents 5 to 10-membered heteroaryl, and 5 to 10-membered heteroaryl may be substituted with 1 or 2 substituents selected independently from the group of halogen, nitro, cyano , (C1-C6) -alkyl, trifluoromethyl, hydroxyl, (C1-C6) -alkoxy, amino, mono-(C1-C6) -alkyl-amino, di-al chyl- (C1-C6) -amino, hydroxycarbonyl, alkoxy- (C1-C6) -carbonyl, aminocarbonyl, mono-C1- C6) -aminocarbonyl, di-C1- C6) -aminocarbonyl, pyrrolidino, piperidino, morpholino, piperazino and N'-alkyl- (C1-C4) -piperazino, phenyl and 5- or 6-membered heteroaryl, and phenyl and 5- or 6-membered heteroaryl may be substituted with 1 to 3 substituents independently selected from the group halogen, nitro, cyano, (C1-C6) alkyl, difluoromethyl, trifluoromethyl, hydroxyl, (C1-C6) alkoxy, difluoromethoxy, trifluoromethoxy, amino, mono-C1-C6-alkyl-amino, di-alkyl- ( C1-C6) - amino, hydroxycarbonyl and alkoxy- (C1-C6) -carbonyl, R2 represents cycloalkyl (C5-C6), 5- or 6-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl, where cycloalkyl (C5- C6) can be substituted with 1 or 2 substituents independently selected from the group of (C1-C6) -alkyl, hydroxyl, oxo, (C1-C6) -alkoxy, amino, mono-(C1-C6) -alkyl-amino and di -alq uil- (C1-C6) -amino, whereby (C1-C6) alkyl and (C1-C6) alkoxy can be substituted with 1 or 2 substituents independently selected from the group of hydroxyl, (C1-C4) alkoxy and (C3 cycloalkyl). -C7), whereby (C3-C7) cycloalkyl may be substituted by 1 or 2 substituents independently selected from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and wherein heterocyclyl 5- or 6-membered may be substituted with 1 to 3 substituents independently selected from the group of oxo, thioxo, hydroxyl, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) -alkyl-carbonyl, amino, mono-(C1-C6) -alkyl-amino, di-(C1-C6) -alkyl-amino and (C3-C7) cycloalkyl, (C1-C6) -alkyl may be substituted with 1 to 3 substituents independently selected from yes from the group of fluorine, oxo, hydroxyl, trifluoromethyl, (C1-C4) alkoxy, alkyl- (C1-C4) -carbonyloxy, amino, mono-(C1-C4) -amino, di-C1- alkyl C4) -amino and cycloa (C3-C7) -alkyl, whereby (C3-C7) cycloalkyl may itself be substituted with 1 or 2 substituents independently selected from the group of (C1-C4) -alkyl, hydroxyl, oxo and (C1-C4) -alkoxy, and the (C1-C6) -alkyl-carbonyl may be substituted with a substituent selected from the group of hydroxyl and (C1-C4) alkoxy, and the (C3-C7) cycloalkyl may be substituted with 1 or 2 substituents independently selected from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and wherein 5- or 6-membered phenyl and heteroaryl may be substituted with 1 to 3 substituents independently selected from the group of halogen, cyano, hydroxyl, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C7) cycloalkoxy, and -NRARB, where (C1-C6) alkyl may be substituted with 1 to 3 substituents selected from the group of fluorine, and where (C1) alkoxy may be -C6) substituted with 1 to 3 substituents independently selected from the group of fl Ășor, trifluoromethyl, (C3-C7) cycloalkyl, oxo, hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl, amino, monoalkyl- (C1-C4) -amino and di-C1- C4-alkyl, -amino, and may be (C3-C7) cycloalkoxy substituted with 1 or 2 substituents independently selected from each other from the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, and representing RA hydrogen or (C1-C6) alkyl, whereby (C1-C6) alkyl may be substituted by a substituent selected from the group of hydroxyl and (C1-C4) alkoxy, RB hydrogen, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-) alkyl. C4) -sulfonyl or cycloalkyl- (C3-C7) -sulfonyl, whereby (C1-C6) alkyl may itself be substituted with 1 or 2 substituents independently selected from the group of (C3-C7) cycloalkyl, oxo, hydroxyl, (C1-C4) alkoxy, hydroxycarbonyl, amino, mono-(C1-C4) -alkyl-amino and di-(C1-C4) -alkyl-amino, and may be substituted by 1-C3-C7-cycloalkyl. or 2 substituents select two independently from each other of the group of (C1-C4) alkyl, hydroxyl, oxo and (C1-C4) alkoxy, or being able to form two adjacent substituents on phenyl together with the carbon atoms to which they are attached 1,3- dioxolane or 2,2-difluoro-1,3-dioxolane, as well as their N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides. |
priorityDate | 2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 881.