http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2535147-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8281ac9f4fb11f15a5da018344453338 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0804 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2004-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99d736b7db72e24937cdd72d67cfc2ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5275be429ea9971d27b92017fc3b55ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92d573083ba72859de14b77d210c438b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fe53405064f14242c6e51f0ee4f547a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96d5f462b2861d07bd0255ba59b34ab9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e8a3f3873f5921eb9f57df16e0757df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c44ced022db2e6edf998d65dcbd470bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b40147b6917e1be028f6ac2767694e8 |
| publicationDate | 2015-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2535147-T3 |
| titleOfInvention | Quinoxalinyl macrocyclic compounds that inhibit hepatitis C serine proteases |
| abstract | A compound of Formula I or a pharmaceutically acceptable salt or ester thereof: ** Formula ** A is independently selected from hydrogen; - (CO) -O-R1, - (C> = O) -R2, -C (> = O) -NH-R2, -C (> = S) -NH-R2, or -S (O) 2 -R2; G is independently selected from -OH, -O- (C1-C12 alkyl), -NHS (O) 2-R1, - (C> = O) -R2; - (C> = O) -O-R1, or - (C> = O) -NH-R2; L is absent; X and Y taken together with the carbon atoms to which they are attached form a cyclic moiety selected from aryl, substituted aryl, heteroaryl, or substituted heteroaryl; W is absent, or is independently selected from -O-, -S-, -NH-, -C (O) NR1- or -NR1-; Z is independently selected from hydrogen; -CN, -SCN, -NCO, -NCS, -NHNH2, -N3, halogen, -R4, - C3-C12 cycloalkyl, -C3-C12 substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl; Each R1 is independently selected from hydrogen, C1-C6 alkyl, substituted C1-C6 alkyl, C2-C6 alkenyl, substituted C2-C6 alkenyl, C2-C6 alkynyl, substituted C2-C6 alkynyl, C3 cycloalkyl -C12, substituted C3-C12 cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl; Each R2 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkyl, substituted C1-C6 alkyl, C2-C6 alkenyl, substituted C2-C6 alkenyl, C2-C6 alkynyl, C2- alkynyl Substituted C6, C3-C12 cycloalkyl, substituted C3-C12 cycloalkyl, alkylamino, dialkylamino, arylamino, diarylamino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, heterocycloalkyl; Each R4 is independently selected from: (i) -C1-C6 alkyl containing 0.1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituents selected from halogen, aryl, aryl substituted, heteroaryl, or substituted heteroaryl; (ii) -C2-C6 alkenyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or substituted heteroaryl ; or (iii) -C2-C6 alkynyl containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N, optionally substituted with one or more substituents selected from halogen, aryl, substituted aryl, heteroaryl, or heteroaryl replaced; R5 and R6 are each hydrogen; j> = 3; m> = 1; and s> = 1. |
| priorityDate | 2003-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 752.