http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2534872-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 |
| filingDate | 2007-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_334c9ffa30c7687a91753998a4e7a9e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dc3aaaaa808f66d47e8f0d94853e8ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e474b9038111d7a8f2cef04659e5688b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_770f8de7e8042840fcc7264ccb495fcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8798e57ade461b74215a2a1da9a8b6db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc56b6d31aeef70559c7be0916039192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08dd5194a61b123cbf059343a2110d31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd959912adc38af92da8060f7bfabd2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe47c4ba836b4c837c0fb37d8818c3ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c400bd8cdacc788a9b627686fe5e9a95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e71e0361759061f8f5644fb9bbb15a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3a2602d82a1af14832f1a4e32f368bf |
| publicationDate | 2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2534872-T3 |
| titleOfInvention | Substituted dihydropyrazolones for the treatment of cardiovascular and hematological diseases |
| abstract | Compound of formula (I) ** Formula ** in which R1 represents a heteroaryl group of formula ** Formula ** in which * means the junction points with the dihydropyrazzolone ring, A means in any individual occurrence C-R4 or N, representing a maximum of two ring members A at the same time N, where R4 in each individual case, independently of one another, represents hydrogen or a substituent selected from the group of fluorine, chlorine, bromine, cyano, nitro, alkyl ( C1-C6), hydroxy, (C1-C6) alkoxy, trifluoromethoxy, amino, mono (C1-C6) alkyl, amino, di (C1-C6) alkyl, amino, hydroxycarbonyl and (C1-C6) alkoxycarbonyl , the said (C1-C6) alkyl moiety may be substituted for up to three times, the same or different, with fluorine, chlorine, bromine, cyano, hydroxy, trifluoromethoxy, (C1-C4) alkoxy, amino, monoalkyl (C1- C4) -amino, di-(C1-C4) alkyl-amino, hydroxycarbonyl and / or (C1-C4) alkoxycarbonyl, and E means O, S or N-R5, where R5 represents hydrogen or (C1-C6) alkyl, R2 represents a heteroaryl group of formula ** Formula ** in which it means the junction points with the dihydropyrazzolone ring, G means respectively C-R6 or N, not representing N more than one of the two G-ring members, wherein R6 in each individual case, independently of one another, represents hydrogen or a substituent selected from the group of fluorine, chlorine, bromine, cyano, (C1-C6) alkyl, cycloalkyl (C3-C6) , 4 to 6 membered heterocycloalkyl, phenyl, 5 or 6 membered heteroaryl, -C (> = O) -OR10, -C (> = O) - NR11R12, -OC (> = O) -R13, -OC ( > = O) -NR14R15, -NR16-C (> = O) -R17, -NR18-C (> = O) -OR19, -NR20-C (> = O) - NR21R22, -NR23-SO2-R24, -OR28 and -NR30R31, where (i) (C1-C6) alkyl may be substituted for its part one to three times, the same or different, with moieties selected from the group of fluorine, chlorine, bromine, cyano, cycloalkyl (C3 -C6), 4-6 membered heterocycloalkyl, phenyl, 5- or 6-membered heteroaryl, -C (> = O) -OR10, -C (> = O) -NR11R 12, -OC (> = O) -R13, - OC (> = O) -NR14R15, -NR16-C (> = O) -R17, -NR18-C (> = O) -OR19, -NR20-C (> = O) -NR21R22, -NR23-SO2-R24, -OR28 and -NR30R31, the cycloalkyl, heterocycloalkyl, phenyl and heteroaryl moieties just mentioned on their part may be substituted respectively up to twice, same or different, with fluorine, chlorine, bromine, cyano, (C1-C4) alkyl, trifluoromethyl, hydroxy, (C1-C4) alkoxy, trifluoromethoxy, oxo, amino, mono (C1-C4) alkyl-amino, di-(C1-C4) alkyl - amino, hydroxycarbonyl and / or (C1-C4) alkoxycarbonyl, (ii) cycloalkyl (C3-C6), 4-6 membered heterocycloalkyl, 5 or 6 membered phenyl and heteroaryl may be substituted for their part respectively one or two times, the same or different, with fluorine, chlorine, bromine, cyano, (C1-C4) alkyl, trifluoromethyl, hydroxy, (C1-C4) alkoxy, trifluoromethoxy, oxo, amino, mono (C1-C4) -amino, di-(C1-C4) alkyl-amino, hydroxycarbonyl and / or (C1-C4) -carbonyl alkoxy, (iii) R10, R11, R13, R14, R17, R19, R21, R24, R28 and R3 0 independently of each other at each individual occurrence represent a moiety selected from the group of hydrogen, (C1-C6) alkyl, cycloalkyl (C3-C6), 4-6 membered heterocycloalkyl, 5 or 6 membered phenyl and heteroaryl, which may be replaced cycloalkyl (C3-C6), heterocycloalkyl of 4 to 6 members, phenyl and heteroaryl of 5 or 6 members respectively respectively up to three times, the same or different, with fluorine, chlorine, bromine, cyano, (C1-C4) alkyl , trifluoromethyl, hydroxy, (C1-C4) alkoxy, trifluoromethoxy, oxo, amino, mono (C1-C4) -amino, di-(C1-C4) -amino, hydroxycarbonyl and / or (C1-C4) alkoxy -carbonyl and (C1-C6) alkyl may be substituted one to three times, the same or different, with fluorine, chlorine, bromine, cyano, hydroxy, trifluoromethoxy, (C1-C4) alkoxy, amino, mono-C1-alkyl C4) -amino, di-(C1-C4) alkyl-amino, hydroxycarbonyl, (C1-C4) alkoxy, cycloalkyl (C3-C6), 4- to 6-membered heterocycloalkyl, phenyl and / or heteroaryl 5 or 6 members, (iv) R12, R15, R16, R18, R20, R22, R23 and R31 independently of each other in each individual occurrence represent a remainder selected from the group of hydrogen and acyl (C1-C6), being able to substituted (C1-C6) alkyl once or twice, the same or different, with fluorine, chlorine, bromine, cyano, hydroxy, trifluoromethoxy, (C1-C4) alkoxy, amino, mono (C1-C4) alkyl-di, -C1-C4 alkyl-amino, hydroxycarbonyl and / or C1-C4-alkoxycarbonyl, and / or where (v) R11 and R12, R14 and R15, R16 and R17, R18 and R19, R20 and R21 , R21 and R22, R23 and R24 as well as R30 and R31 can respectively form in pairs together with the atoms to which they are attached, a 5- or 6-membered heterocycloalkyl ring, which may be substituted once or twice, same or different, with fluorine, chlorine, bromine, cyano, (C1-C4) alkyl, trifluoromethyl, hydroxy, (C1-C4) alkoxy, trifluoromethoxy, oxo, amino, mono (C1-C4) alkyl-amino, di-alkyl (C1- C4) -amino, hydroxycarbonyl and / or (C1-C4) alkoxy-carbonyl, and J means O or S, and R3 represents hydrogen or methyl, as well as its salts, solvates and solvates of the salts. |
| priorityDate | 2006-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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