| abstract |
Pharmaceutical dosage form showing a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an anionic polysaccharide (B) that is obtained by introducing anionic functional groups, in protonated form or physiologically acceptable salt thereof, into a polysaccharide selected from the group consisting of carboxymethylcellulose, carboxymethyl starch, croscarmellose and carrageenan; and a polyalkylene oxide (C); wherein the pharmacologically active ingredient (A) is present in a controlled release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C). |