| abstract |
An oral pharmaceutical composition of doxycycline which, at a single daily dosage, will provide blood levels in equilibrium of doxycycline of a minimum of approximately 0.1 μg / ml and a maximum of approximately 1.0 μg / ml, which is a combination of a component containing doxycycline in an immediate release (IR) formulation and a second component containing doxycycline in a delayed release (DR) formulation, in which the ratio of IR to DR is 80:20 a 70:30, in which the composition contains between 25 and 50 mg of doxycycline. |